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Infection-induced IL-10 and JAK-STAT: A review of the molecular circuitry controlling immune hyperactivity in response to pathogenic microbes
Journal article   Open access   Peer reviewed

Infection-induced IL-10 and JAK-STAT: A review of the molecular circuitry controlling immune hyperactivity in response to pathogenic microbes

Alison J. Carey, Chee K. Tan and Glen C. Ulett
JAK-STAT, v 1(3), pp 159-167
01 Jul 2012
DOI: https://doi.org/10.4161/jkst.19918
PMID: 24058765
url
https://www.tandfonline.com/doi/pdf/10.4161/jkst.19918?needAccess=trueView
Published, Version of Record (VoR) Open
url
https://doi.org/10.4161/jkst.19918View
Published, Version of Record (VoR) Open

Abstract

host response infection and immunity interleukin-10 microbes microbial pathogenesis molecular and cellular biology
Generation of effective immune responses against pathogenic microbes depends on a fine balance between pro- and anti-inflammatory responses. Interleukin-10 (IL-10) is essential in regulating this balance and has garnered renewed interest recently as a modulator of the response to infection at the JAK-STAT signaling axis of host responses. Here, we examine how IL-10 functions as the "master regulator" of immune responses through JAK-STAT, and provide a perspective from recent insights on bacterial, protozoan, and viral infection model systems. Pattern recognition and subsequent molecular events that drive activation of IL-10-associated JAK-STAT circuitry are reviewed and the implications for microbial pathogenesis are discussed.

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