Journal article
Inflammasomes in wound healing and fibrosis
The Journal of pathology, v 229(2)
Jan 2013
PMID: 23023641
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Inflammasome signalling and downstream cytokine responses mediated by the inflammasome have been found to play an important role, not only in wound healing but also in fibrosis. The inflammasome regulates the secretion of IL-1β and IL-18 cytokines, and both are critical for the repair of damaged tissue and play a role in fibrosis. However, what dictates the fine balance between normal wound healing versus fibrosis is yet to be fully elucidated. Further investigations into the role of the inflammasomes in these pathologies will be important for the discovery of novel therapeutics that can abrogate fibrosis or promote wound healing in chronic disease.
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Details
- Title
- Inflammasomes in wound healing and fibrosis
- Creators
- Carol M Artlett - Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA 19129, USA. carol.artlett@drexelmed.edu
- Publication Details
- The Journal of pathology, v 229(2)
- Publisher
- Wiley; England
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000312542400003
- Scopus ID
- 2-s2.0-84871055429
- Other Identifier
- 991014878262804721
UN Sustainable Development Goals (SDGs)
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Oncology
- Pathology