Journal article
Inflammation, Functional Status, and Weight Loss During Recovery From Cardiac Surgery in Older Adults: A Pilot Study
Biological research for nursing, v 16(3), pp 344-352
01 Jul 2014
PMID: 24057224
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objective: To determine the nutritional, inflammatory, and functional aspects of unintentional weight loss after cardiac surgery that warrant further investigation. Research Methods and Procedures: Twenty community-dwelling adults >= 65 years old undergoing cardiac surgery (coronary artery bypass graft [CABG] or CABG + valve) were recruited for this prospective longitudinal (preoperative and 4-6 weeks postdischarge) pilot study. Anthropometrics (weight, standing height, and mid-arm and calf circumference), nutritional status (Mini-Nutritional Assessment(TM) [MNA]), appetite, physical performance (timed chair stand), muscle strength (hand grip) and functional status (basic and instrumental activities of daily living), and inflammatory markers (plasma leptin, ghrelin, interleukin [IL]-6, high-sensitivity[hs] C-reactive protein, and serum albumin and prealbumin) were measured. Results: Participants who completed the study (n = 11 males, n = 3 females) had a mean age 70.21 +/- 4.02 years. Of these, 12 lost 3.66 +/- 1.44 kg over the study period. Weight, BMI, activities of daily living, and leptin decreased over time (p < .05). IL-6 increased over time (p < .05). Ghrelin, hs-CRP, and timed chair stand increased over time in those who underwent combined procedures (p < .05). Grip strength decreased in those who developed complications (p = .004). Complications, readmission status, and lowered grip strength were found in those with low preoperative MNA scores (p < .05). Conclusion: After cardiac surgery, postdischarge weight loss occurs during a continued inflammatory response accompanied by decreased physical functioning and may not be a positive outcome. The impacts of weight loss, functional impairment, and inflammation during recovery on disability and frailty warrant further study.
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Details
- Title
- Inflammation, Functional Status, and Weight Loss During Recovery From Cardiac Surgery in Older Adults: A Pilot Study
- Creators
- Rose Ann DiMaria-Ghalili - Drexel UniversityEileen M. Sullivan-Marx - College of Nursing, New York University New York, NY, USACharlene Compher - University of Pennsylvania
- Publication Details
- Biological research for nursing, v 16(3), pp 344-352
- Publisher
- Sage
- Number of pages
- 9
- Grant note
- UL1RR024134 / National Center for Research Resources from National Institutes of Health's National Center for Research Resources UL1RR024134 / NATIONAL CENTER FOR RESEARCH RESOURCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) American Academy of Nursing Building Academic Geriatric Capacity Fellowship Program
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Nursing and Health Professions
- Web of Science ID
- WOS:000342389700013
- Scopus ID
- 2-s2.0-84904996426
- Other Identifier
- 991019168115204721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Nursing