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Journal article
Inflammation and Oxidative Stress in Multiple Sclerosis: Consequences for Therapy Development
Oxidative medicine and cellular longevity, v 2020, 7191080
2020
PMID: 32454942
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
CNS inflammation is a major driver of MS pathology. Differential immune responses, including the adaptive and the innate immune system, are observed at various stages of MS and drive disease development and progression. Next to these immune-mediated mechanisms, other mediators contribute to MS pathology. These include immune-independent cell death of oligodendrocytes and neurons as well as oxidative stress-induced tissue damage. In particular, the complex influence of oxidative stress on inflammation and vice versa makes therapeutic interference complex. All approved MS therapeutics work by modulating the autoimmune response. However, despite substantial developments in the treatment of the relapsing-remitting form of MS, approved therapies for the progressive forms of MS as well as for MS-associated concomitants are limited and much needed. Here, we summarize the contribution of inflammation and oxidative stress to MS pathology and discuss consequences for MS therapy development.
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Details
- Title
- Inflammation and Oxidative Stress in Multiple Sclerosis: Consequences for Therapy Development
- Creators
- Valentina Pegoretti - University of GroningenKathryn A Swanson - Drexel UniversityJohn R Bethea - Drexel UniversityLesley Probert - Pasteur Hellenic InstituteUlrich L M Eisel - University of GroningenRoman Fischer - University of Stuttgart
- Publication Details
- Oxidative medicine and cellular longevity, v 2020, 7191080
- Publisher
- Wiley
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biology; Neurobiology and Anatomy
- Web of Science ID
- WOS:000537261800001
- Scopus ID
- 2-s2.0-85085538538
- Other Identifier
- 991019169620904721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Cell Biology