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Journal article
Inflammation and cardiac dysfunction during sepsis, muscular dystrophy, and myocarditis
Burns and trauma, v 1(3), pp 109-121
18 Dec 2013
PMID: 27574633
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Inflammation plays an important role in cardiac dysfunction under different situations. Acute systemic inflammation occurring in patients with severe burns, trauma, and inflammatory diseases causes cardiac dysfunction, which is one of the leading causes of mortality in these patients. Acute sepsis decreases cardiac contractility and impairs myocardial compliance. Chronic inflammation such as that occurring in Duchenne muscular dystropshy and myocarditis may cause adverse cardiac remodeling including myocyte hypertrophy and death, fibrosis, and altered myocyte function. However, the underlying cellular and molecular mechanisms for inflammatory cardiomyopathy are still controversial probably due to multiple factors involved. Potential mechanisms include the change in circulating blood volume; a direct inhibition of myocyte contractility by cytokines (tumor necrosis factor (TNF)-α, interleukin (IL)-1β); abnormal nitric oxide and reactive oxygen species (ROS) signaling; mitochondrial dysfunction; abnormal excitation-contraction coupling; and reduced calcium sensitivity at the myofibrillar level and blunted β-adrenergic signaling. This review will summarize recent advances in diagnostic technology, mechanisms, and potential therapeutic strategies for inflammation-induced cardiac dysfunction.
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Details
- Title
- Inflammation and cardiac dysfunction during sepsis, muscular dystrophy, and myocarditis
- Creators
- Ying Li - Temple UniversityShuping Ge - Drexel UniversityYizhi Peng - Army Medical UniversityXiongwen Chen - Temple University
- Publication Details
- Burns and trauma, v 1(3), pp 109-121
- Publisher
- BioMed Central
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:000218607900018
- Scopus ID
- 2-s2.0-84921435640
- Other Identifier
- 991019167670304721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Dermatology
- Emergency Medicine
- Surgery