Journal article
Inflammatory Bowel Disease Following Allogeneic Hematopoietic Cell Transplant for Sickle Cell Disease
Pediatric blood & cancer, v 73(1), e32121
Jan 2026
PMID: 41116703
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Although graft-versus-host disease (GvHD) is an important cause of gastrointestinal (GI) complications after allogeneic hematopoietic stem cell transplantation (HCT), the non-specific symptoms make diagnosis challenging. We described three patients with sickle cell disease who developed inflammatory bowel disease (IBD) like manifestations 4-18 months post-HCT. All patients received peripheral blood stem cell grafts and sirolimus for GvHD prophylaxis. All had chronic diarrhea, and biopsies showed extensive colonic ulceration, non-necrotizing granulomas, with minimal histologic evidence of GvHD. Symptoms resolved promptly with IBD-directed therapy. Our report highlights the importance of considering alternative rare etiologies for GI complications such as IBD after HCT.
Metrics
2 Record Views
Details
- Title
- Inflammatory Bowel Disease Following Allogeneic Hematopoietic Cell Transplant for Sickle Cell Disease
- Creators
- Emily Rowland - Nationwide Children's HospitalAkshay Sharma - St. Jude Children's Research HospitalSamantha Paglinco - Children's Hospital of PhiladelphiaRoss M Maltz - Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Nationwide Children's Hospital, Columbus, Ohio, USAJeffrey E Deyo - Our Lady of the Lake Children's HospitalKiran Joglekar - University of Tennessee Health Science CenterJohn Brannon Alberty - Arkansas Children’s FoundationCourtney Fitzhugh - National Heart Lung and Blood InstituteHemalatha G Rangarajan - Nationwide Children's Hospital
- Publication Details
- Pediatric blood & cancer, v 73(1), e32121
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:001596360000001
- Scopus ID
- 2-s2.0-105019223864
- Other Identifier
- 991022170451604721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Hematology
- Oncology
- Pediatrics