Journal article
Influence of Concurrent Anastrozole on Acute and Late Side Effects of Whole Breast Radiotherapy
American journal of clinical oncology, v 34(3), pp 245-248
01 Jun 2011
PMID: 20622644
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objectives: To retrospectively compare radiation toxicity in patients treated with concurrent anastrozole and whole breast irradiation versus women treated sequentially with whole breast irradiation followed by hormonal suppression.
Methods: The records of 249 consecutive estrogen or progesterone receptor positive breast cancer patients treated with breast-conserving surgery and postoperative whole breast irradiation were reviewed. Of total, 57 patients (the concurrent anastrozole group) received concurrent anastrozole prior to and during radiotherapy. In 126 patients (the sequential group), adjuvant hormone suppression therapy (anastrozole, other aromatase inhibitors, or tamoxifen) was administered after the completion of breast irradiation. In 66, women either concurrent tamoxifen was given with radiation or the sequence of hormonal therapy was not known. These women were excluded from the analysis.
Results: The frequency of acute grade 2 radiation dermatitis (24.6% in the concurrent anastrozole group vs. 20.6% in the sequential group; P = 0.55), grade 3 radiation dermatitis (8.8% vs. 7.1%; P = 0.77) and treatment interruptions due to skin reactions (14.0% vs. 11.2%; P = 0.69) did not differ between groups. The rates of clinically detectable breast fibrosis were not different (24.2% vs. 24.7%; P = 0.97). With a median follow-up of 28 months and 30.8 months, respectively, 1 local failure occurred in the concurrent anastrozole group and 5 in the sequential group.
Conclusions: Anastrozole, administered concurrently with whole breast irradiation, did not increase acute or late morbidity when compared with sequential administration of radiation and hormonal suppression therapy.
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Details
- Title
- Influence of Concurrent Anastrozole on Acute and Late Side Effects of Whole Breast Radiotherapy
- Creators
- Vladimir Valakh - Allegheny General HospitalMark G. Trombetta - Allegheny Gen Hosp, Dept Radiat Oncol, Pittsburgh, PA 15212 USAE. D. Werts - Allegheny Gen Hosp, Dept Radiat Oncol, Pittsburgh, PA 15212 USAGeorge Labban - Western Penn Hosp, Div Hematol Oncol, Pittsburgh, PA 15224 USAMian K. Khalid - Western Penn Hosp, Div Hematol Oncol, Pittsburgh, PA 15224 USAAnna Kaminsky - Lake Erie Coll Osteopath Med, Erie, PA USADavid Parda - Allegheny Gen Hosp, Dept Radiat Oncol, Pittsburgh, PA 15212 USA
- Publication Details
- American journal of clinical oncology, v 34(3), pp 245-248
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 4
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Radiation Oncology (and Nuclear Medicine); Radiology (Radiologic Sciences)
- Web of Science ID
- WOS:000290943500006
- Scopus ID
- 2-s2.0-79958273846
- Other Identifier
- 991019169428804721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Oncology