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Journal article
Influence of Microgel and Interstitial Matrix Compositions on Granular Hydrogel Composite Properties
Advanced science, pp e2206117-e2206117
30 Jan 2023
PMID: 36717272
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Granular hydrogels are an emerging class of biomaterials formed by jamming hydrogel microparticles (i.e., microgels). These materials have many advantageous properties that can be tailored through microgel design and extent of packing. To enhance the range of properties, granular composites can be formed with a hydrogel interstitial matrix between the packed microgels, allowing for material flow and then stabilization after crosslinking. This approach allows for distinct compartments (i.e., microgels and interstitial space) with varied properties to engineer complex material behaviors. However, a thorough investigation of how the compositions and ratios of microgels and interstitial matrices influence material properties has not been performed. Herein, granular hydrogel composites are fabricated by combining fragmented hyaluronic acid (HA) microgels with interstitial matrices consisting of photocrosslinkable HA. Microgels of varying compressive moduli (10-70 kPa) are combined with interstitial matrices (0-30 vol.%) with compressive moduli varying from 2-120 kPa. Granular composite structure (confocal imaging), mechanics (local and bulk), flow behavior (rheology), and printability are thoroughly assessed. Lastly, variations in the interstitial matrix chemistry (covalent vs guest-host) and microgel degradability are investigated. Overall, this study describes the influence of granular composite composition on structure and mechanical properties of granular hydrogels towards informed designs for future applications.
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Details
- Title
- Influence of Microgel and Interstitial Matrix Compositions on Granular Hydrogel Composite Properties
- Creators
- Victoria G Muir - University of PennsylvaniaShoshana Weintraub - University of PennsylvaniaAbhishek P Dhand - University of PennsylvaniaHooman Fallahi - Drexel UniversityLin Han - Drexel UniversityJason A Burdick - University of Pennsylvania
- Publication Details
- Advanced science, pp e2206117-e2206117
- Publisher
- Wiley
- Grant note
- R01HL160616 to J.A.B / NIH HHS DMR-1720530 / National Science Foundation R01AR077362 / NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000918400900001
- Scopus ID
- 2-s2.0-85147030294
- Other Identifier
- 991019961075604721
UN Sustainable Development Goals (SDGs)
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Chemistry, Multidisciplinary
- Materials Science, Multidisciplinary
- Nanoscience & Nanotechnology