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Journal article
Influence of Spine Curvature on the Efficacy of Transcutaneous Lumbar Spinal Cord Stimulation
Journal of clinical medicine, v 10(23), p5543
01 Dec 2021
PMID: 34884249
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Transcutaneous spinal cord stimulation is a non-invasive method for neuromodulation of sensorimotor function. Its main mechanism of action results from the activation of afferent fibers in the posterior roots-the same structures as targeted by epidural stimulation. Here, we investigated the influence of sagittal spine alignment on the capacity of the surface-electrode-based stimulation to activate these neural structures. We evaluated electromyographic responses evoked in the lower limbs of ten healthy individuals during extension, flexion, and neutral alignment of the thoracolumbar spine. To control for position-specific effects, stimulation in these spine alignment conditions was performed in four different body positions. In comparison to neutral and extended spine alignment, flexion of the spine resulted in a strong reduction of the response amplitudes. There was no such effect on tibial-nerve evoked H reflexes. Further, there was a reduction of post-activation depression of the responses to transcutaneous spinal cord stimulation evoked in spinal flexion. Thus, afferent fibers were reliably activated with neutral and extended spine alignment. Spinal flexion, however, reduced the capacity of the stimulation to activate afferent fibers and led to the co-activation of motor fibers in the anterior roots. This change of action was due to biophysical rather than neurophysiological influences. We recommend applying transcutaneous spinal cord stimulation in body positions that allow individuals to maintain a neutral or extended spine.
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Details
- Title
- Influence of Spine Curvature on the Efficacy of Transcutaneous Lumbar Spinal Cord Stimulation
- Creators
- Veronika E. Binder - Vienna Univ Technol, Inst Anal & Sci Comp, A-1040 Vienna, AustriaUrsula S. Hofstoetter - Med Univ Vienna, Ctr Med Phys & Biomed Engn, A-1090 Vienna, AustriaAnna Rienmueller - Med Univ Vienna, Dept Orthoped & Trauma Surg, A-1090 Vienna, AustriaZoltan Szava - Austrian Workers Compensat Board, Competence Ctr Med Tech, A-1200 Vienna, AustriaMatthias J. Krenn - Univ Mississippi, Med Ctr, Dept Neurobiol & Anat, Jackson, MS 39216 USAKaren Minassian - Med Univ Vienna, Ctr Med Phys & Biomed Engn, A-1090 Vienna, AustriaSimon M. Danner - Drexel University
- Publication Details
- Journal of clinical medicine, v 10(23), p5543
- Publisher
- Mdpi
- Number of pages
- 17
- Grant note
- R01 NS115900; R01 NS112304 / National Institutes of Health (NIH); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA I 3837-B34 / Austrian Science Fund (FWF)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000741452500001
- Scopus ID
- 2-s2.0-85119929850
- Other Identifier
- 991019167426404721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Neurosciences