Journal article
Influence of environmental conditions on a new surfactant-based contrast agent: ST68
Ultrasound in medicine & biology, v 26(4), pp 621-628
2000
PMID: 10856625
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Environmental influences on the new surfactant-stabilized bubbles, ST68, were investigated. We have developed a new surfactant-based contrast agent ST68, which is prepared by insonating buffered mixtures of Span 60 and Tween 80 in the presence of either air, PFC, or SF
6 gas. The effect of dilution, shear, and sonication on size distribution of ST68 showed that PFC-containing bubbles (ST68-PFC) were most stable. ST68-PFC bubbles lasted more than 15 min with ∼ 30 dB backscatter enhancement in degassed phosphate-buffered saline, (pH 7.4), and air bubbles lasted ∼ 3 s, suggesting the effects of diffusion. Additionally, it was found that the ionic strength of the suspending medium (for example, PBS), did not have any effect on ST68 bubbles containing SF
6 or PFC, but had a dramatic impact on bubbles containing air.
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Details
- Title
- Influence of environmental conditions on a new surfactant-based contrast agent: ST68
- Creators
- Raghuveer Basude - Drexel UniversityJeffrey W. Duckworth - Drexel UniversityMargaret A. Wheatley - Drexel University
- Publication Details
- Ultrasound in medicine & biology, v 26(4), pp 621-628
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000087497600013
- Scopus ID
- 2-s2.0-0034117219
- Other Identifier
- 991019169691404721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Acoustics
- Radiology, Nuclear Medicine & Medical Imaging