Journal article
Influence of levels of carbon dioxide and oxygen upon gasping in perfused rat preparation
Respiration physiology, v 129(3), pp 279-287
2002
PMID: 11788131
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
In vivo, the augmenting pattern of integrated phrenic nerve discharge of eupnea is altered to the decrementing pattern of gasping in severe hypoxia or ischaemia. Identical alterations in phrenic discharge are found in perfused in situ preparations of the juvenile rat. In this preparation, gasping was produced by equilibration of the perfusate with various levels of carbon dioxide and oxygen. The duration of the phrenic burst, the interval between bursts and the burst amplitude were not significantly different following equilibration with 21–6%O
2 at 5% CO
2 or with 0–9% CO
2 at 6% O
2, with the exception that the burst amplitude was significantly greater in hypercapnic-hypoxia (9% CO
2 at 6% O
2). It is proposed that hypoxia-induced gasping results from the release of an endogenous pacemaker activity of rostral medullary neurons. This release is caused by cellular mechanisms that change the balance between membrane ionic currents. Moreover, these cellular mechanisms may be explicitly induced by alterations in the ionic and metabolic homeostasis.
Metrics
Details
- Title
- Influence of levels of carbon dioxide and oxygen upon gasping in perfused rat preparation
- Creators
- Walter M St.-John - Dartmouth-Hitchcock Medical Center, Department of Physiology, Dartmouth Medical School, Borwell Building, Lebanon, NH 03756, USAIlya A Rybak - School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA 19104, USA
- Publication Details
- Respiration physiology, v 129(3), pp 279-287
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000173627900001
- Scopus ID
- 2-s2.0-0036157211
- Other Identifier
- 991014878426104721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Physiology
- Respiratory System