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Journal article
Influence of short-term exposure to ultrafine and fine particles on systemic inflammation
European journal of epidemiology, v 25(8), pp 581-592
01 Aug 2010
PMID: 20559688
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Daily to monthly variations in fine particulate matter have been linked to systemic inflammatory responses. It has been hypothesized that smaller particles resulting from combustion processes confer higher toxicity. We aim to analyze the association between short-term exposure to ultrafine and fine particles and systemic inflammation. We use baseline data (2000-2003) of the Heinz Nixdorf Recall Study, a population-based cohort study of 4,814 participants in the Ruhr Area in Germany. A chemistry transport model was applied to model daily surface concentrations of particulate air pollutants on a grid of 1 km(2). Exposure included particle number (PN) and particulate matter mass concentration with an aerodynamic diameter a parts per thousand currency sign2.5 mu m (PM2.5) and a parts per thousand currency sign10 mu m (PM10). Generalized additive models were used to explore the relation of air pollutants using single day lags and averaging times of up to 28 days with high-sensitivity C-reactive protein (hs-CRP). We adjusted for meteorology, season, time trend, and personal characteristics. Median hs-CRP level in the 3,999 included participants was 1.5 mg/l. Median daily concentration of PN was 8,414 x 10(4)/ml (IQR 4,580 x 10(4)/ml), of PM2.5 14.5 mu g/mA(3) (IQR 11.5 mu g/mA(3)) and of PM10 18.5 mu g/mA(3) (IQR 13.9 mu g/mA(3)). A positive association between PN and hs-CRP could be observed only for single day lags and for averaged PN concentrations with higher estimates for longer averaging times. The highest hs-CRP-increase of 7.1% (95%-CI: 1.9, 12.6%) was found for the 21-day average. These results support the hypothesis that short-term exposure to traffic-related particles might lead to detrimental cardiovascular health effects via an inflammatory mechanism.
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Details
- Title
- Influence of short-term exposure to ultrafine and fine particles on systemic inflammation
- Creators
- Sabine Hertel - University of Duisburg-EssenAnja Viehmann - Essen University HospitalSusanne Moebus - Essen University HospitalKlaus Mann - Essen University HospitalMartina Broecker-Preuss - Univ Hosp Essen, Dept Endocrinol, D-45122 Essen, GermanyStefan Moehlenkamp - University of Duisburg-EssenMichael Nonnemacher - Essen University HospitalRaimund Erbel - University of Duisburg-EssenHermann Jakobs - Rhenish Institute for Environmental ResearchMichael Memmesheimer - Rhenish Institute for Environmental ResearchKarl-Heinz Joeckel - College Station Medical CenterBarbara Hoffmann - Essen University Hospital
- Publication Details
- European journal of epidemiology, v 25(8), pp 581-592
- Publisher
- Springer Nature
- Number of pages
- 12
- Grant note
- JO 170/8-1 / DFG; German Research Foundation (DFG) German Ministry of Education and Science
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000280907500008
- Scopus ID
- 2-s2.0-77956192323
- Other Identifier
- 991020100058704721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Public, Environmental & Occupational Health