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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Influence of vitamin D and estrogen receptor gene polymorphisms on calcium absorption: BsmI predicts a greater decrease during energy restriction
Bone (New York, N.Y.), v 81, pp 138-144
09 Jul 2015
PMID: 26165414
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Low calcium absorption is associated with low bone mass and fracture. In this study, we use gold standard methods of fractional calcium absorption (FCA) to determine whether polymorphisms of intestinal receptors, vitamin D receptor
(VDR)
and estrogen receptor α (
ESR1
), influence the response to energy restriction. Fractional calcium absorption was measured using dual stable isotopes (
42
Ca and
43
Ca) in women given adequate calcium and vitamin D and examined at baseline and after 6 weeks of energy restriction or no intervention. After genotyping, the relationship between
VDR
and
ESR1
genotypes/haplotypes and FCA response was assessed using several genetic models. One-hundred and sixty-eight women (53 ± 11 years of age) were included in this analysis. The
ESR1
polymorphisms,
Pvu
II and
Xba
I and
VDR
polymorphisms (
Taq
I,
Apa
I) did not significantly influence FCA. The
BB
genotype of the
VDR
polymorphism,
BsmI
, was associated with a greater decrease in FCA than the
Bb/ bb
genotype. Multiple linear regression showed that the
Bsm
I polymorphism or the
VDR
haplotype,
BAt,
in addition to changes in weight and vitamin D intake explained ~16% of the variation in changes in FCA. In conclusion, the reduction in calcium absorption due to energy restriction is greatest for those with the
BB
genotype. Previous candidate gene studies show that
VDR
polymorphisms are associated with higher risk for osteoporosis, and the current study supports the notion that the
Bsm
I polymorphism in intestinal VDR may be contributing to alterations in bone health.
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Details
- Title
- Influence of vitamin D and estrogen receptor gene polymorphisms on calcium absorption: BsmI predicts a greater decrease during energy restriction
- Creators
- Chang B - Department of Nutritional Sciences, Rutgers University, New Brunswick, NJ Drexel University, Philadelphia, PA Department of Medicine, Rutgers-Robert Wood Johnson University HospitalSchlussel Y - Department of Nutritional Sciences, Rutgers University, New Brunswick, NJ Drexel University, Philadelphia, PA Department of Medicine, Rutgers-Robert Wood Johnson University HospitalSukumar D - Department of Nutritional Sciences, Rutgers University, New Brunswick, NJ Drexel University, Philadelphia, PA Department of Medicine, Rutgers-Robert Wood Johnson University HospitalSchneider SH - Department of Nutritional Sciences, Rutgers University, New Brunswick, NJ Drexel University, Philadelphia, PA Department of Medicine, Rutgers-Robert Wood Johnson University HospitalShapses SA - Department of Nutritional Sciences, Rutgers University, New Brunswick, NJ Drexel University, Philadelphia, PA Department of Medicine, Rutgers-Robert Wood Johnson University HospitalBor-Chin Chang - Mechanical Engineering and Mechanics
- Publication Details
- Bone (New York, N.Y.), v 81, pp 138-144
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Mechanical Engineering and Mechanics; Nutrition Sciences
- Web of Science ID
- WOS:000365372800019
- Scopus ID
- 2-s2.0-84937122591
- Other Identifier
- 991019168830804721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Endocrinology & Metabolism