Journal article
Infralimbic prefrontal cortex interacts with nucleus accumbens shell to unmask expression of outcome-selective Pavlovian-to-instrumental transfer
Learning & memory (Cold Spring Harbor, N.Y.), v 22(10), pp 509-513
Oct 2015
PMID: 26373829
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Although several studies have examined the subcortical circuitry underlying Pavlovian-to-instrumental transfer (PIT), the role of medial prefrontal cortex in this behavior is largely unknown. Elucidating the cortical contributions to PIT will be key for understanding how reward-paired cues control behavior in both adaptive and maladaptive context (i.e., addiction). Here we use bilateral lesions in a rat model to show that infralimbic prefrontal cortex (ilPFC) is necessary for appropriate expression of PIT. Further, we show that ilPFC mediates this effect via functional connectivity with nucleus accumbens shell (NAcS). Together, these data provide the first demonstration that a specific cortico-striatal circuit is necessary for cue-invigorated reward seeking during specific PIT.
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Details
- Title
- Infralimbic prefrontal cortex interacts with nucleus accumbens shell to unmask expression of outcome-selective Pavlovian-to-instrumental transfer
- Creators
- Colby Keistler - Yale UniversityJacqueline M Barker - Yale UniversityJane R Taylor - Yale University
- Publication Details
- Learning & memory (Cold Spring Harbor, N.Y.), v 22(10), pp 509-513
- Publisher
- American Physical Society (APS)
- Number of pages
- 5
- Grant note
- R01 DA011717 / NIDA NIH HHS P50 AA012870 / NIAAA NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:000362971900002
- Scopus ID
- 2-s2.0-84946059616
- Other Identifier
- 991020100187304721
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- Web of Science research areas
- Neurosciences
- Psychology, Experimental