Journal article
Inherited Interleukin 2-Inducible T-Cell (ITK) Kinase Deficiency in Siblings With Epidermodysplasia Verruciformis and Hodgkin Lymphoma
Clinical infectious diseases, v 68(11), pp 1938-1941
17 May 2019
PMID: 30778533
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Biallelic mutations in the ITK gene cause a T-cell primary immunodeficiency with Epstein-Barr virus (EBV)-lymphoproliferative disorders. We describe a novel association of a homozygous ITK mutation with -human papillomavirus (HPV)-positive epidermodysplasia verruciformis. Thus, loss of function in ITK can result in broad dysregulation of T-cell responses to oncogenic viruses, including -HPV and EBV.
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Details
- Title
- Inherited Interleukin 2-Inducible T-Cell (ITK) Kinase Deficiency in Siblings With Epidermodysplasia Verruciformis and Hodgkin Lymphoma
- Creators
- Leila Youssefian - Thomas Jefferson Univ, Sidney Kimmel Med Coll, Dept Dermatol & Cutaneous Biol, 233 S 10th St,Suite 450 BLSB, Philadelphia, PA 19107 USAHassan Vahidnezhad - Thomas Jefferson Univ, Sidney Kimmel Med Coll, Dept Dermatol & Cutaneous Biol, 233 S 10th St,Suite 450 BLSB, Philadelphia, PA 19107 USAMehdi Yousefi - Tabriz University of Medical SciencesAmir Hossein Saeidian - Thomas Jefferson Univ, Sidney Kimmel Med Coll, Dept Dermatol & Cutaneous Biol, 233 S 10th St,Suite 450 BLSB, Philadelphia, PA 19107 USAArghavan Azizpour - Tehran University of Medical SciencesAndrew Touati - Thomas Jefferson Univ, Sidney Kimmel Med Coll, Dept Dermatol & Cutaneous Biol, 233 S 10th St,Suite 450 BLSB, Philadelphia, PA 19107 USANeda Nikbakht - Thomas Jefferson Univ, Sidney Kimmel Med Coll, Dept Dermatol & Cutaneous Biol, 233 S 10th St,Suite 450 BLSB, Philadelphia, PA 19107 USAKambiz Kamyab-Hesari - University of TehranMohammad Mahdi Adib-Sereshki - Iran University of Medical SciencesSirous Zeinali - Kawsar Human Genet Res Ctr, Tehran, IranBehzad Mansoori - Tabriz University of Medical SciencesAli Jazayeri - Drexel UniversityRazieh Karamzadeh - Royan InstitutePaolo Fortina - Thomas Jefferson UniversityEmmanuelle Jouanguy - Rockefeller UniversityJean-Laurent Casanova - Rockefeller Univ, Rockefeller Branch, St Giles Lab Human Genet Infect Dis, 1230 York Ave, New York, NY 10021 USAJouni Uitto - Thomas Jefferson Univ, Sidney Kimmel Med Coll, Dept Dermatol & Cutaneous Biol, 233 S 10th St,Suite 450 BLSB, Philadelphia, PA 19107 USA
- Publication Details
- Clinical infectious diseases, v 68(11), pp 1938-1941
- Publisher
- Oxford Univ Press
- Number of pages
- 4
- Grant note
- Rockefeller University Institut National de la Sante et de la Recherche Medicale, Paris Descartes University Department of Dermatology and Cutaneous Biology of Thomas Jefferson University R21 AI107508-02 / National Institute of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA St. Giles Foundation
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine
- Web of Science ID
- WOS:000469504700022
- Scopus ID
- 2-s2.0-85061155640
- Other Identifier
- 991021860699804721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Immunology
- Infectious Diseases
- Microbiology