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Journal article
Inhibition of Ataxia Telangiectasia Mutated (ATM) Kinase Suppresses Herpes Simplex Virus Type 1 (HSV-1) Keratitis
Investigative ophthalmology & visual science, v 55(2), pp 706-715
01 Feb 2014
PMID: 24370835
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
This study shows that inhibition of ATM, an apical kinase in the mammalian DNA damage response pathway, suppresses HSV-1 replication in corneal epithelial cells and explanted human and rabbit corneas. ATM inhibition also reduces stromal keratitis severity in mice without causing corneal toxicity.
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Details
- Title
- Inhibition of Ataxia Telangiectasia Mutated (ATM) Kinase Suppresses Herpes Simplex Virus Type 1 (HSV-1) Keratitis
- Creators
- Oleg Alekseev - Drexel UniversityKelly Donovan - Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, Philadelphia, PennsylvaniaJane Azizkhan-Clifford - Drexel University
- Publication Details
- Investigative ophthalmology & visual science, v 55(2), pp 706-715
- Publisher
- The Association for Research in Vision and Ophthalmology
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- [Retired Faculty]
- Web of Science ID
- WOS:000331891700009
- Scopus ID
- 2-s2.0-84893289156
- Other Identifier
- 991019169555704721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Ophthalmology