Journal article
Inhibition of Calmodulin‐Stimulated Phosphodiesterase Activity by Vasoactive Intestinal Peptide
Journal of neurochemistry, v 45(2), pp 640-643
Aug 1985
PMID: 2989433
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
: The effects of certain peptides of the glucagon family on calmodulin activity were determined from their capacity to inhibit a calmodulin‐dependent form of phosphodiesterase. Vasoactive intestinal peptide and secretin were potent inhibitors of calmodulin activity, having IC50 values of 0.5 μM and 2 μM, respectively. By contrast, glucagon failed to inhibit calmodulin activity even at concentrations of 100 μM. None of these compounds significantly inhibited the basal activity of phosphodiesterase at concentrations up to 100 μM. These findings support the suggestion that important structural features of peptides for anticalmodulin activity include a net positive charge and a hydrophobic surface.
Metrics
Details
- Title
- Inhibition of Calmodulin‐Stimulated Phosphodiesterase Activity by Vasoactive Intestinal Peptide
- Creators
- Mary S. Barnette - York College of PennsylvaniaBenjamin Weiss - York College of Pennsylvania
- Publication Details
- Journal of neurochemistry, v 45(2), pp 640-643
- Publisher
- Blackwell Publishing Ltd
- Number of pages
- 4
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:A1985AMB5800045
- Scopus ID
- 2-s2.0-0022391166
- Other Identifier
- 991019184086204721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biochemistry & Molecular Biology
- Neurosciences