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Inhibition of PCR-based assay for Bordetella pertussis by using calcium alginate fiber and aluminum shaft components of a nasopharyngeal swab
Journal article   Open access   Peer reviewed

Inhibition of PCR-based assay for Bordetella pertussis by using calcium alginate fiber and aluminum shaft components of a nasopharyngeal swab

R M Wadowsky, S Laus, T Libert, S J States and G D Ehrlich
Journal of clinical microbiology, v 32(4), pp 1054-1057
Apr 1994
PMID: 8027309
url
https://doi.org/10.1128/JCM.32.4.1054-1057.1994View
Published, Version of Record (VoR) Open

Abstract

A PCR-based assay for Bordetella pertussis was inhibited by using a calcium alginate fiber-tipped swab with an aluminum shaft but not by using a Dacron fiber-tipped swab with a plastic shaft. The calcium alginate fiber component inhibited the assay following storage for less than 1 min in a suspension of 10(3) CFU of B. pertussis per ml, whereas the aluminum shaft component required storage for at least 48 h in order to cause inhibition. We recommend the Dacron swab over the calcium alginate swab for collecting specimens for testing in PCR-based assays.

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Microbiology
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