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Journal article
Inhibition of dopamine release with simultaneous chemosensory excitation by hypercapnia with and without [Ca 2+] 0 in the cat carotid body
Journal of the autonomic nervous system, v 69(2), pp 184-189
1998
PMID: 9696275
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The hypothesis that dopamine (DA) overflow corresponds to carotid sinus nerve (CSN) discharge during hypercapnia and is dependent on [Ca
2+]
0 was tested. We simultaneously measured the time course of DA overflow and CSN discharge of the cat carotid body, perfused/superfused in vitro at 37°C at decreasing [Ca
2+]
0, during transition from normocapnia (P
CO
2
∼30–35 Torr) to hypercapnia (P
CO
2
∼60–65 Torr). In the presence of normal [Ca
2+]
0, hypercapnia instantaneously increased nerve discharge to peak levels followed by a decrease to steady states which were above the basal rate of activity. CSN discharge rate did not differ at decreasing [Ca
2+]
0 between 2.2 and 1.0 mM, and it began to decline at 0.1 mM [Ca
2+]
0, culminating to zero level in most cases, at zero [Ca
2+]
0. DA overflow increased slightly during hypercapnic peak CSN activity. Thereafter it declined to steady state levels below those of normocapnic conditions. Decreases in steady state DA levels were significantly less at 0 mM [Ca
2+]
0 compared to the higher calcium concentrations (0.1, 1.0 and 2.2 mM). Overall, steady state CSN activity and DA overflow were inversely related. Thus, DA release cannot have excitatory implications for carotid chemoreceptors during hypercapnia in the cat.
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Details
- Title
- Inhibition of dopamine release with simultaneous chemosensory excitation by hypercapnia with and without [Ca 2+] 0 in the cat carotid body
- Creators
- Charmaine Rozanov - University of PennsylvaniaDonald G Buerk - University of PennsylvaniaDeepak Chugh - University of PennsylvaniaAnil Mokashi - University of PennsylvaniaSukhamay Lahiri - University of Pennsylvania
- Publication Details
- Journal of the autonomic nervous system, v 69(2), pp 184-189
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000074543400014
- Scopus ID
- 2-s2.0-0032580216
- Other Identifier
- 991019231631804721
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- Web of Science research areas
- Neurosciences