Journal article
Inhibition of kinesin-5, a microtubule-based motor protein, as a strategy for enhancing regeneration of adult axons
Traffic (Copenhagen, Denmark), v 12(3), pp 269-286
Mar 2011
PMID: 21166743
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Developing neurons express a motor protein called kinesin-5 (also called kif11 or Eg5) which acts as a “brake” on the advance of the microtubule array during axonal growth. Pharmacological inhibition of kinesin-5 causes the developing axon to grow at a faster rate, retract less, and grow past cues that would other wise cause it to turn. Here we demonstrate that kinesin-5 is also expressed in adult neurons, albeit at lower levels than during development. We hypothesized that inhibiting kinesin-5 might enable adult axons to regenerate better, and to overcome repulsive molecules associated with injury. Using adult mouse dorsal root ganglion neurons, we found that anti-kinesin-5 drugs cause axons to grow faster and to cross with higher frequency onto inhibitory chondroitin sulfate proteoglycans (CSPGs). These effects may be due in part to changes in the efficiency of microtubule transport along the axonal shaft as well as enhanced microtubule entry into the distal tip of the axon. Effects observed with the drugs are further enhanced in some cases when they are used in combination with other treatments known to enhance axonal regeneration. Collectively, these results indicate that anti-kinesin-5 drugs may be a useful addition to the arsenal of tools used to treat nerve injury.
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Details
- Title
- Inhibition of kinesin-5, a microtubule-based motor protein, as a strategy for enhancing regeneration of adult axons
- Creators
- Shen Lin - Department of Neurobiology and Anatomy, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PAMei Liu - Department of Neurobiology and Anatomy, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PAYoung-Jin Son - Department of Neurobiology and Anatomy, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PAB. Timothy Himes - Department of Neurobiology and Anatomy, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PADiane M Snow - Spinal Cord and Brain Injury Research Center and Department of Anatomy and Neurobiology, University of Kentucky, Lexington, KYWenqian Yu - Department of Neurobiology and Anatomy, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PAPeter W Baas - Department of Neurobiology and Anatomy, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA
- Publication Details
- Traffic (Copenhagen, Denmark), v 12(3), pp 269-286
- Publisher
- Wiley
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000287199000004
- Scopus ID
- 2-s2.0-79751469568
- Other Identifier
- 991014877837604721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Cell Biology