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Inhibition of macrophage-induced antigen-specific T-cell proliferation by interferon-γ
Journal article   Peer reviewed

Inhibition of macrophage-induced antigen-specific T-cell proliferation by interferon-γ

Lisa Nurmi McKernan, Kenneth J. Blank, George L. Spitalny and Donna Marie Murasko
Cellular immunology, v 114(2), pp 432-439
01 Jul 1988
DOI: https://doi.org/10.1016/0008-8749(88)90334-6
PMID: 2455606
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

The effects of IFN-γ on macrophage (Mφ)-mediated antigen-specific T-cell proliferation was investigated. A well-defined assay system using purified resident populations of antigen-pulsed peritoneal Mφ and immune T cells was used to measure Mφ-induced antigen-specific T-cell proliferation. Antibody affinity purified or recombinant IFN-γ inhibited Mφ-induced T-cell proliferation when KLH-pulsed Mφ from mice given IFN-γ prior to KLH were cultured with KLH immune T cells from normal mice. Monoclonal rat anti-IFN-γ antibody neutralized the inhibitory effect of IFN-γ. This inhibition of T-cell proliferation occurred despite the fact that these Mφ appeared to be activated by IFN-γ treatment as measured by increased tumoricidal activity. The mechanism for the inhibition was unrelated to class II (Ia) expression, IL-1 secretion, and prostaglandin secretion. These results demonstrate the complex and sensitive role IFN-γ has in regulating the immune response.

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Collaboration types
Industry collaboration
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Web of Science research areas
Cell Biology
Immunology
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