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Journal article
Inhibition of macrophage-induced antigen-specific T lymphocyte proliferation by poly I:C: Strain and antigen independence
Cellular immunology, v 135(1), pp 16-26
Jun 1991
PMID: 1902145
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Abstract
We have previously demonstrated that IFN-
α
β
poly I:C (an inducer of IFN-
α
β
), and IFN-γ can inhibit the ability of KLH-pulsed peritoneal macrophages to induce proliferation of syngeneic, KLH immune T lymphocytes in CBA/J mice. In this study, we show that this IFN-induced immunosuppression is not restricted to CBA/J (H-2
k) mice but is also seen in BALB/cJ (H-2
d) mice. A similar inhibition of proliferation is observed with the KLH-specific T cell hybridoma BDK. 100, which requires KLH-pulsed macrophages for optimum proliferation and IL-2 production. The immunosuppression produced by IFN was also independent of the antigen employed. Inhibition of T lymphocyte proliferation was observed when casein, instead of KLH, was used to immunize T cells and to pulse peritoneal macrophages
in vivo. Utilizing KLH and casein, the antigen specificity of the inhibition was demonstrated. Therefore, the inhibition by the IFN-inducer poly I:C of macrophage-induced, antigen-specific T cell proliferation is not limited by H-2 type of the mice or to one antigen.
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Details
- Title
- Inhibition of macrophage-induced antigen-specific T lymphocyte proliferation by poly I:C: Strain and antigen independence
- Creators
- Dawn A. Kirschmann - Drexel UniversityDonna M. Murasko - Drexel University
- Publication Details
- Cellular immunology, v 135(1), pp 16-26
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biology
- Web of Science ID
- WOS:A1991FK34500002
- Scopus ID
- 2-s2.0-0025734889
- Other Identifier
- 991020950770904721
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Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Cell Biology
- Immunology