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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Inhibitory control of sensory gating in a computer model of the CA3 region of the hippocampus
Biological cybernetics, v 88(4)
01 Apr 2003
PMID: 12690484
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
A model of the CA3 region of the hippocampus was used to simulate the P50 auditory-evoked potential response to repeated stimuli in order to study the neuronal circuits involved in a sensory-processing deficit associated with schizophrenia. Normal subjects have a reduced P50 auditory-evoked potential amplitude in response to the second of two paired auditory click stimuli spaced 0.5 s apart. However, schizophrenic patients do not gate or reduce their response to the second click. They have equal auditory-evoked response amplitudes to both clicks. When schizophrenic patients were medicated with traditional neuroleptics, the evoked potential amplitude to both clicks increased, but gating of the second response was not restored or improved. Animal studies suggest a role for septohippocampal cholinergic activity in sensory gating. We used a computational model of this system in order to study the relative contributions of local processing and afferent activity in sensory gating. We first compared the effect of information representation as average firing rate to information representation as cell assemblies in order to evaluate the best method to represent the response of hippocampal neurons to the auditory click. We then studied the effects of nicotinic cholinergic input on the response of the network and the effect of GABA
B
receptor activation on the ability of the local network to suppress the test response. The results of our model showed that nicotinic cholinergic input from the septum to the hippocampus can control the flow of sensory information from the cortex into the hippocampus. In addition, postsynaptic GABA
B
receptor activation was not sufficient to suppress the test response when the interstimulus interval was 500 ms. However, presynaptic GABA
B
receptor activity may be responsible for the suppression of the test response at this interstimulus interval.
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Details
- Title
- Inhibitory control of sensory gating in a computer model of the CA3 region of the hippocampus
- Creators
- Karen A. Moxon - Drexel UniversityGreg A. Gerhardt - University of KentuckyMaria Gulinello - Department of Physiology, State University of New York at Brooklyn, Brooklyn, NY 11203 USA, , USLawrence E. Adler - University of Colorado Health
- Publication Details
- Biological cybernetics, v 88(4)
- Publisher
- Springer Nature
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000182789900001
- Scopus ID
- 2-s2.0-0142039670
- Other Identifier
- 991019168453904721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Computer Science, Cybernetics
- Neurosciences