Journal article
Inhibitory properties of low molecular mass cysteine proteinase inhibitors from human sarcoma
Biochimica et biophysica acta, Protein structure and molecular enzymology, Vol.993(1), pp.63-73
01 Jan 1989
Abstract
Elevated activities of cysteine proteinases such as cathepsins B and L and cancer procoagulant have been linked to tumor malignancy. The authors examined the hypothesis that these elevated activities could be due to impaired regulation by the endogenous low molecular mass cysteine proteinase inhibitors (cystatins). Inhibitors from human sarcoma were compared to those from human liver, a normal tissue in which the inhibitors had been characterized previously. An extract of cystatins from sarcoma was less effective against papain and cathepsin B (liver or tumor) than was an extract from liver. This reduced inhibitory capacity in sarcoma was not due to a reduction in either the concentrations or specific activities of the cystatins or an absence of any family or isoform of cystatins.
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Details
- Title
- Inhibitory properties of low molecular mass cysteine proteinase inhibitors from human sarcoma
- Creators
- T LahJ CliffordK HelmerN A DayK MoinK HonnJ CrissmanB Sloane
- Publication Details
- Biochimica et biophysica acta, Protein structure and molecular enzymology, Vol.993(1), pp.63-73
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology; [Retired Faculty]
- Identifiers
- 991020202230104721