Journal article
Initial Patient Characteristics of TSOG 102: A Multicenter Prospective Registry of Active Surveillance in Patients with Multiple Ground Glass Opacities
The Journal of thoracic and cardiovascular surgery, v 169(4)
10 Oct 2024
PMID: 39395785
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Presentation with multiple ground glass opacities (GGOs) is an increasingly common occurrence, and the optimal management of these lesions is unclear. Active surveillance has been increasingly adopted as a management strategy for other low-grade malignancies. We hypothesized that active surveillance could be a feasible and safe option for patients with multiple GGOs.
Patients with ≥2 GGOs (ground glass predominant, <50% solid, ≤3 cm) were enrolled in a multi-institutional registry and prospectively followed up on active surveillance with computed tomography scans every 6 to 12 months. Each GGO was catalogued and measured individually at each follow-up visit.
Target accrual was met, with 337 patients from 23 institutions. The mean age was 70 years (interquartile range, 65-77 years), and 74% were women. Most were former (70%) or current (9%) smokers, with a mean exposure of 30 pack-years (interquartile range [IQR], 15-44 pack-years). Half of the patients (51%) had a previous lung cancer, and the majority (86%) were already under surveillance at the time of study entry. The median number of GGOs per patient was 3 (IQR, 2-5), with a total of 1467 GGOs under surveillance. The median GGO size was 0.9 cm (IQR, 0.7-1.3 cm). Most GGOs were 0.5 to 1 cm in size.
Active surveillance, rather than immediate intervention, was an acceptable option to patients, and accrual to this registry trial was feasible. Safety endpoints and long-term outcomes will be assessed in the planned 5-year follow-up in accordance with the protocol.
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Details
- Title
- Initial Patient Characteristics of TSOG 102: A Multicenter Prospective Registry of Active Surveillance in Patients with Multiple Ground Glass Opacities
- Creators
- James Huang - Memorial Sloan Kettering Cancer CenterKay See Tan - Memorial Sloan Kettering Cancer CenterNasser Altorki - New York Hospital QueensMara Antonoff - The University of Texas MD Anderson Cancer CenterShanda Blackmon - Mayo Clinic in ArizonaRaphael Bueno - Brigham and Women's HospitalBryan Burt - Houston Institute for Clinical ResearchTodd Demmy - Roswell Park Comprehensive Cancer CenterNathaniel Evans - Thomas Jefferson UniversityLaura Donahoe - University Health NetworkDavid Harpole - Duke Medical CenterDoraid Jarrar - University of PennsylvaniaBenjamin Kozower - Washington University in St. LouisMichael Lanuti - Massachusetts General HospitalMoishe Liberman - Université de MontréalJules Lin - Michigan MedicineDouglas Liou - Stanford UniversityMichael Liptay - Rush University Medical CenterJames Luketich - University of PittsburghArjun Pennathur - University of PittsburghGerard Petersen - Lehigh Valley Hospital-PoconoRobert Ripley - Baylor College of MedicineMatthew Rochefort - Brigham and Women's HospitalChristopher W. Seder - Rush University Medical CenterJoseph Shrager - Stanford UniversityStacey Su - Fox Chase Cancer CenterBetty Tong - Duke Medical CenterYaron Shargall - McMaster UniversityAra Vaporciyan - The University of Texas MD Anderson Cancer CenterThomas Waddell - University Health NetworkBenny Weksler - Allegheny Health NetworkDennis Wigle - Mayo Clinic in ArizonaSai Yendamuri - Roswell Park Comprehensive Cancer CenterDavid R. Jones - Memorial Sloan Kettering Cancer Center
- Publication Details
- The Journal of thoracic and cardiovascular surgery, v 169(4)
- Publisher
- Elsevier; NEW YORK
- Number of pages
- 8
- Grant note
- Cancer Center Support Grant: P30 CA008748
Supported by Cancer Center Support Grant P30 CA008748 (to Memorial Sloan Ket-tering Cancer Center) .
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Surgery
- Web of Science ID
- WOS:001457728400001
- Scopus ID
- 2-s2.0-85210769943
- Other Identifier
- 991021960802704721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Cardiac & Cardiovascular Systems
- Respiratory System
- Surgery