Journal article
Initial experience with bioactive cerecyte detachable coils: Impact on reducing recurrence rates
Neurosurgery, v 62(4), pp 799-805
01 Apr 2008
PMID: 18496185
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
OBJECTIVE: Despite proven safety of endovascular coil embolization of intracranial aneurysms, the potential need for retreatment remains criticized. The goal of this prospective study was to assess the safety, durability, and effect on recanalization rates of the Cerecyte (Micrus Corp., Sunnyvale, CA) bioactive coil.
METHODS: Two hundred twelve ruptured and unruptured aneurysms in 176 patients were prospectively enrolled in a database registry during a 12-month period. Adverse clinical outcomes directly attributed to the use of the Cerecyte coil were documented. Angiographic outcomes were determined immediately after coil embolization and during follow-up studies. All patients who received stent assistance or a non-Cerecyte coil were excluded. Two independent endovascular surgeons reviewed follow-up films. Any discrepancy was deemed a recurrence.
RESULTS: After exclusion criteria, 81 patients with 89 aneurysms were available for a minimum of 6 months of follow-up. Of those 89 aneurysms, 65% were ruptured aneurysms and were treated in the acute setting. The mean size of the aneurysm was 7 mm. The mean angiographic follow-up period was 11.2 months. Recurrences requiring retreatment as a result of dome filling were identified in six aneurysms (6.7%). Four aneurysms (4%) developed compaction of more than 20%, which was defined as interstitial filling of the fundus. There was one thromboembolic event leading to permanent neurological deficit. No cases of chemical meningitis or delayed hydrocephalus occurred.
CONCLUSION: The Cerecyte bioactive coil seems to be safe and effective for use in both ruptured and unruptured aneurysms. The bioactive polymer within the coils allows similar handling characteristics of a bare platinum coil. Studies to assess long-outcomes with direct comparison to platinum coils and alternative bioactive coils are warranted.
Metrics
4 Record Views
Details
- Title
- Initial experience with bioactive cerecyte detachable coils: Impact on reducing recurrence rates
- Creators
- Erol Veznedaroglu - Thomas Jefferson UniversityChristopher J. Koebbe - Thomas Jefferson UniversityAdnan Siddiqui - Thomas Jefferson UniversityRobert H. Rosenwasser - Thomas Jefferson University
- Publication Details
- Neurosurgery, v 62(4), pp 799-805
- Publisher
- Oxford Univ Press
- Number of pages
- 7
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurosurgery
- Web of Science ID
- WOS:000255429300018
- Scopus ID
- 2-s2.0-67249098521
- Other Identifier
- 991021962188304721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Clinical Neurology
- Surgery