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Initiated CVD of Poly(2‐Hydroxyethyl Methacrylate) Hydrogels: Synthesis, Characterization and In‐vitro Biocompatibility
Journal article

Initiated CVD of Poly(2‐Hydroxyethyl Methacrylate) Hydrogels: Synthesis, Characterization and In‐vitro Biocompatibility

Ranjita K Bose and Kenneth K. S Lau
Chemical vapor deposition, v 15(4‐6)
Jun 2009

Abstract

PHEMA initiated CVD hydrogel cell adhesion cytotoxicity
Initiated (i)CVD, an all‐dry, one‐step surface polymerization technique, was used to synthesize thin film hydrogels of poly (2‐hydroxyethyl methacrylate) (PHEMA). Fourier transform infrared (FTIR) and nuclear magnetic resonance (NMR) spectroscopies showed stoichiometric PHEMA films obtained by iCVD. Differential scanning calorimetry (DSC) revealed a high glass transition temperature, indicative of high molecular mass polymer. In‐vitro cell studies using adult human dermal fibroblasts (HDF) demonstrated the nontoxic nature and good cell adhesion properties of iCVD PHEMA films. Full Paper: Initiated chemical vapor deposition, an all‐dry, one‐step surface polymerization technique was used to synthesize thin film hydrogels of poly (2‐hydroxyethyl methacrylate). Chemical properties and in vitro biocompatibility of the films were tested. FTIR and NMR results evidenced excellent compositional stoichiometry, while cell adhesion and cytotoxicity tests showed good biocompatibility, thus suggesting strong potential for biological applications.

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Web of Science research areas
Electrochemistry
Materials Science, Coatings & Films
Physics, Condensed Matter
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