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Journal article
Injectable Nano-Network for Glucose-Mediated Insulin Delivery
ACS nano, v 7(5), pp 4194-4201
01 May 2013
PMID: 23638642
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Diabetes mellitus, a disorder of glucose regulation, is a global burden affecting 366 million people across the world. An artificial "closed-loop" system able to mimic pancreas activity and release insulin in response to glucose level changes has the potential to improve patient compliance and health. Herein we develop a glucose-mediated release strategy for the self-regulated delivery of insulin using an injectable and acid-degradable polymeric network. Formed by electrostatic interaction between oppositely charged dextran nanoparticles loaded with insulin and glucose-specific enzymes, the nanocomposite-based porous architecture can be dissociated and subsequently release insulin in a hyperglycemic state through the catalytic conversion of glucose into gluconic acid. In vitro insulin release can be modulated in a pulsatile profile in response to glucose concentrations. In vivo studies validated that these formulations provided improved glucose control in type 1 diabetic mice subcutaneously administered with a degradable nano-network. A single injection of the developed nano-network facilitated stabilization of the blood glucose levels in the normoglycemic state (<200 mg/dL) for up to 10 days.
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Details
- Title
- Injectable Nano-Network for Glucose-Mediated Insulin Delivery
- Creators
- Zhen Gu - Massachusetts Institute of TechnologyAlex A. Aimetti - Massachusetts Institute of TechnologyQun Wang - Massachusetts Institute of TechnologyTram T. Dang - Massachusetts Institute of TechnologyYunlong Zhang - Massachusetts Institute of TechnologyOmid Veiseh - Massachusetts Institute of TechnologyHao Cheng - Drexel UniversityRobert S. Langer - Massachusetts Institute of TechnologyDaniel G. Anderson - Massachusetts Institute of Technology
- Publication Details
- ACS nano, v 7(5), pp 4194-4201
- Publisher
- American Chemical Society; Washington, DC
- Number of pages
- 8
- Grant note
- 09PG-T1D027 / Leona M. and Harry B. Helmsley Charitable Trust Foundation P30CA014051 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Materials Science and Engineering
- Web of Science ID
- WOS:000319856300056
- Scopus ID
- 2-s2.0-84878339119
- Other Identifier
- 991019169798004721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Chemistry, Multidisciplinary
- Chemistry, Physical
- Materials Science, Multidisciplinary
- Nanoscience & Nanotechnology