Journal article
Innate and Adaptive Factors Regulating Human Immunodeficiency Virus Type 1 Genomic Activation
Journal of neuroimmune pharmacology, v 5(3), pp 278-293
Sep 2010
PMID: 20387125
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Over the past decade, antiretroviral therapy targeting the viral entry process, reverse transcriptase, integrase, and protease, has prolonged the lives of people infected with human immunodeficiency virus type 1 (HIV-1). However, despite the development of more effective therapeutic strategies, reservoirs of viral infection remain. This review discusses molecular mechanisms surrounding the development of latency from the site of integration to pre- and post-integration maintenance of latency, including epigenetic factors. In addition, an overview of innate and adaptive cells important to HIV-1 infection are examined from the viewpoint of cytokines released and cytokines that act on these cells to explore an overall understanding of HIV-1 proviral genome activation. Finally, this review is discussed from the viewpoint of how an understanding of the interplay of all of these factors will help guide the next generation of therapies.
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Details
- Title
- Innate and Adaptive Factors Regulating Human Immunodeficiency Virus Type 1 Genomic Activation
- Creators
- Sonia Shah - Institute for Molecular Medicine and Infectious Disease Drexel University College of Medicine School of Medicine Philadelphia PA USAMichael Nonnemacher - Institute for Molecular Medicine and Infectious Disease Drexel University College of Medicine School of Medicine Philadelphia PA USAVanessa Pirrone - Institute for Molecular Medicine and Infectious Disease Drexel University College of Medicine School of Medicine Philadelphia PA USABrian Wigdahl - Institute for Molecular Medicine and Infectious Disease Drexel University College of Medicine School of Medicine Philadelphia PA USA
- Contributors
- Jacobson Steven (Editor)
- Publication Details
- Journal of neuroimmune pharmacology, v 5(3), pp 278-293
- Publisher
- Springer US; Boston
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000280597700003
- Scopus ID
- 2-s2.0-77955984711
- Other Identifier
- 991014877954104721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Neurosciences
- Pharmacology & Pharmacy