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Journal article
Innovation and constraint leading to complex multicellularity in the Ascomycota
Nature communications, v 8(1), 14444
08 Feb 2017
PMID: 28176784
Abstract
The advent of complex multicellularity (CM) was a pivotal event in the evolution of animals, plants and fungi. In the fungal Ascomycota, CM is based on hyphal filaments and arose in the Pezizomycotina. The genus Neolecta defines an enigma: phylogenetically placed in a related group containing mostly yeasts, Neolecta nevertheless possesses Pezizomycotina-like CM. Here we sequence the Neolecta irregularis genome and identify CM-associated functions by searching for genes conserved in Neolecta and the Pezizomycotina, which are absent or divergent in budding or fission yeasts. This group of 1,050 genes is enriched for functions related to diverse endomembrane systems and their organization. Remarkably, most show evidence for divergence in both yeasts. Using functional genomics, we identify new genes involved in fungal complexification. Together, these data show that rudimentary multicellularity is deeply rooted in the Ascomycota. Extensive parallel gene divergence during simplification and constraint leading to CM suggest a deterministic process where shared modes of cellular organization select for similarly configured organelle- and transport-related machineries.
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Details
- Title
- Innovation and constraint leading to complex multicellularity in the Ascomycota
- Creators
- Tu Anh Nguyen - Temasek Life Sciences LaboratoryOusmane H. Cisse - University of California, RiversideJie Yun Wong - Temasek Life Sciences LaboratoryPeng Zheng - Temasek Life Sciences LaboratoryDavid Hewitt - Acad Nat Sci Philadelphia, Dept Bot, Philadelphia, PA 19103 USAMinou Nowrousian - Ruhr University BochumJason E. Stajich - University of California, RiversideGregory Jedd - Temasek Life Sciences Laboratory
- Publication Details
- Nature communications, v 8(1), 14444
- Publisher
- Springer Nature
- Number of pages
- 13
- Grant note
- Temasek Life Sciences Laboratory; National University of Singapore USDA Agriculture Experimental Station at the University of California-Riverside A.P. Sloan Foundation; Alfred P. Sloan Foundation DFG NO407/5-1 / German Research Foundation; German Research Foundation (DFG) Department of General and Molecular Botany Singapore Millennium Foundation 151780 / Swiss National Science Foundation; Swiss National Science Foundation (SNSF) CA-R-PPA-5062-H / NIFA Hatch project P01 GM068087 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Academy of Natural Sciences of Drexel University
- Web of Science ID
- WOS:000393458800001
- Scopus ID
- 2-s2.0-85011967259
- Other Identifier
- 991021880115004721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Multidisciplinary Sciences