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Innovations in Brachytherapy in Gynecologic Oncology
Journal article   Open access   Peer reviewed

Innovations in Brachytherapy in Gynecologic Oncology

Luther W. Brady, Bizhan Micaily, Curtis T. Miyamoto, Hans‐Peter Heilmann and Paolo Montemaggi
Cancer, v 76(S10), pp 2143-2151
15 Nov 1995
PMID: 8635014
url
https://doi.org/10.1002/1097-0142(19951115)76:10+<2143::aid-cncr2820761339>3.0.co;2-4View
Published, Version of Record (VoR)Maybe Open Access (Publisher Bronze) Open
url
https://doi.org/10.1002/1097-0142(19951115)76:10+<2143::AID-CNCR2820761339>3.0.CO;2-4View
Published, Version of Record (VoR) Open

Abstract

brachytherapy external‐beam radiation therapy radionuclides
With the discovery of radium by Curie in 1898, researchers recognized that this unique radionuclide had specific biologic properties that were applicable to treating patients with cancer. In the beginning, the radium sources were placed within cavities as independent sources and, when needles were available, implanted into tissues. The first combination of brachytherapy technologies with external‐beam radiation therapy was reported by Wright at the Memorial Sloan‐Kettering Cancer Center in New York in 1914 in the treatment of a patient with cervical cancer. Next, there was a rapid implementation of brachytherapy in the treatment of cancer by intracavitary placement of radionuclides, interstitial implantation technologies, and systemic administrations. With the development of new radionuclides, including cesium‐137, cobalt‐60, iridium‐192, iodine‐125, palladium‐103, ruthenium‐109, strontium‐90, iodine‐131, and californium‐225, which had varying types of radiation emissions appropriate when properly selected in treatment of cancer, there was a rapid development of innovative technologies to treat all malignancies, especially gynecologic cancer. The evolution of events brought forth new applicators and techniques that allowed for better distribution of the radiation dosage within the tumor being treated, safer use of radionuclides, and the development of computer programs allowing for varying source applications and dose distributions within the volume implanted. Cancer 1995; 76:2143–51.

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Collaboration types
Domestic collaboration
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Web of Science research areas
Oncology
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