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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Insecticide exposure and farm history in relation to risk of lymphomas and leukemias in the Women's Health Initiative observational study cohort
Annals of epidemiology, v 25(11), pp 803-810
Nov 2015
PMCID: PMC5435453
PMID: 26365305
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Relationships of farm history and insecticide exposure at home or work with lymphohematopoietic (LH) neoplasm risk were investigated in a large prospective cohort of US women.
In questionnaires, women self-reported history living or working on a farm, personally mixing or applying insecticides, insecticide application in the home or workplace by a commercial service, and treating pets with insecticides. Relationships with non-Hodgkin lymphoma (NHL), chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), diffuse large B-cell lymphoma (DLBCL), follicular lymphoma, plasma cell neoplasms, and myeloid leukemia were investigated using Cox proportional hazard models. Age and farming history were explored as effect modifiers.
The analysis included 76,493 women and 822 NHL cases. Women who ever lived or worked on a farm had 1.12 times the risk of NHL (95% confidence interval [CI] = 0.95–1.32) compared to those who did not. Women who reported that a commercial service ever applied insecticides in their immediate surroundings had 65% higher risk of CLL/SLL (95% CI = 1.15–2.38). Women aged less than 65 years who ever applied insecticides had 87% higher risk of DLBCL (95% CI = 1.13–3.09).
Insecticide exposures may contribute to risk of CLL/SLL and DLBCL. Future studies should examine relationships of LH subtypes with specific types of household insecticides.
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Details
- Title
- Insecticide exposure and farm history in relation to risk of lymphomas and leukemias in the Women's Health Initiative observational study cohort
- Creators
- Leah H. Schinasi - Drexel UniversityAnneclaire J. De Roos - Drexel UniversityRoberta M. Ray - Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South AfricaKerstin L. Edlefsen - University of WashingtonChristine G. Parks - National Institute of Environmental Health SciencesBarbara V. Howard - Georgetown-Howard Universities Center for Clinical and Translational ScienceJaymie R. Meliker - Stony Brook UniversityMatthew R. Bonner - University at Buffalo, State University of New YorkRobert B. Wallace - University of IowaAndrea Z. LaCroix - University of California, San Diego
- Publication Details
- Annals of epidemiology, v 25(11), pp 803-810
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Environmental and Occupational Health
- Web of Science ID
- WOS:000363602300001
- Scopus ID
- 2-s2.0-84945459399
- Other Identifier
- 991019168738904721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Public, Environmental & Occupational Health