Journal article
Insight on the Role of Poly(acrylic acid) for Directing Calcium Phosphate Mineralization of Synthetic Polymer Bone Scaffolds
ACS applied bio materials, v 5(9), pp 4493-4503
19 Sep 2022
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Bone is a complex tissue with robust mechanical and biological properties originating from its nanoscale composite structure. Although much research has been conducted on designing bioinspired artificial bone, the role of biological macromolecules such as noncollagenous proteins (NCPs) in influencing the formation of biominerals is not fully understood. In this work, we have designed nanofiber shish-kebab (NFSK) structures that can template mineral location by recruiting calcium cations from an ion-rich mineralization solution. Poly(acrylic acid) (PAA) is used as the NCP analogue to understand the role of polyelectrolytes in scaffold mineralization. We demonstrate that the addition of PAA in the mineralization solution suppresses the development of extrafibrillar minerals as well as slows down the accumulation and development of mineral phases within NFSKs. We probe the mechanism behind this effect by monitoring the free calcium ion concentration, investigating the PAA molecular weight effect, and conducting mineralization in membrane-partitioned solutions. Our results suggest the 2-fold effect of PAA as a solution stabilizer and physical barrier on the NFSK surface. This work could shed light on the understanding of the NCP effect in biomineralization.
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Details
- Title
- Insight on the Role of Poly(acrylic acid) for Directing Calcium Phosphate Mineralization of Synthetic Polymer Bone Scaffolds
- Creators
- Sarah E. Gleeson - Drexel UniversitySeyong Kim - Drexel UniversityTony Yu - Drexel UniversityMichele Marcolongo - Drexel UniversityChristopher Y. Li - Drexel UniversitySeung-Lae Kim - Decision Sciences (and Management Information Systems)
- Publication Details
- ACS applied bio materials, v 5(9), pp 4493-4503
- Publisher
- American Chemical Society; Washington, DC
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Decision Sciences (and Management Information Systems); Materials Science and Engineering
- Web of Science ID
- WOS:000850867500001
- Scopus ID
- 2-s2.0-85137849837
- Other Identifier
- 991019173577204721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Materials Science, Biomaterials
- Nanoscience & Nanotechnology