Journal article
Instant Neurons: Directed Somatic Cell Reprogramming Models of Central Nervous System Disorders
Biological psychiatry (1969), v 75(12), pp 945-951
15 Jun 2014
PMID: 24525100
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Nuclear transplantation, cell fusion, and induced pluripotent stem cell studies have revealed a surprising degree of plasticity in mature mammalian cell fates. Somatic cell reprogramming also has been achieved more recently by the directed conversion of nonneuronal somatic cells, such as skin fibroblasts, to neuronal phenotypes. This approach appears particularly applicable to the in vitro modeling of human neurologic disorders. Central nervous system neurons are otherwise difficult to obtain from patients with neurologic disorders; however, nonhuman models may not reflect patient pathology. Somatic cell reprogramming may afford models of nonfamilial "sporadic" neurologic disorders, which are likely caused by multiple interacting genetic and nongenetic factors. Directed somatic cell reprogramming, which does not pass through typical in vivo developmental stages, toward many mature neuronal phenotypes has now been described. This article reviews the field and discusses the potential utilities of such models, such as for the development of personalized medicine strategies.
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Details
- Title
- Instant Neurons: Directed Somatic Cell Reprogramming Models of Central Nervous System Disorders
- Creators
- Liang Qiang - Columbia UniversityKeiichi Inoue - Departments of Pathology, Cell Biology, and Neurology, and Taub Institute, Columbia University, New York, New YorkAsa Abeliovich - Departments of Pathology, Cell Biology, and Neurology, and Taub Institute, Columbia University, New York, New York
- Publication Details
- Biological psychiatry (1969), v 75(12), pp 945-951
- Publisher
- Elsevier
- Number of pages
- 7
- Grant note
- Merck Laboratories; Merck & Company Union chimique belge Pharma
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000336365200007
- Scopus ID
- 2-s2.0-84901508573
- Other Identifier
- 991019201384404721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Neurosciences
- Psychiatry