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Journal article
Insulin Signaling Misregulation underlies Circadian and Cognitive Deficits in a Drosophila Fragile X Model
Molecular psychiatry, v 22(8), pp 1140-1148
01 Aug 2017
PMID: 27090306
Abstract
Fragile X syndrome (FXS) is an undertreated neurodevelopmental disorder characterized by low IQ and a wide range of other symptoms including disordered sleep and autism. Although FXS is the most prevalent inherited cause of intellectual disability, its mechanistic underpinnings are not well understood. Using Drosophila as a model of FXS, we showed that select expression of dfmr1 in the insulin-producing cells (IPCs) of the brain was sufficient to restore normal circadian behavior and to rescue the memory deficits in the fragile X mutant fly. Examination of the insulin-signaling (IS) pathway revealed elevated levels of Drosophila insulin-like peptide 2 (Dilp2) in the IPCs and elevated IS in the dfmr1 mutant brain. Consistent with a causal role for elevated IS in dfmr1 mutant phenotypes, expression of dfmr1 specifically in the IPCs reduced IS, and genetic reduction of the insulin pathway also led to amelioration of circadian and memory defects. Furthermore we showed that treatment with the FDA approved drug metformin also rescued memory. Finally, we showed that reduction of IS is required at different time points to rescue circadian behavior and memory. Our results indicate that insulin misregulation underlies the circadian and cognitive phenotypes displayed by the Drosophila fragile X model, and thus reveal a metabolic pathway that can be targeted by new and already approved drugs to treat fragile X patients.
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Details
- Title
- Insulin Signaling Misregulation underlies Circadian and Cognitive Deficits in a Drosophila Fragile X Model
- Creators
- Rachel E. Monyak - University of PennsylvaniaDanielle Emerson - Raymond and Ruth Perelman School of Medicine at the University of PennsylvaniaBrian P. SchoenfeldXiangzhong Zheng - Howard Hughes Medical InstituteDaniel B. Chambers - University of AlbertaCory RosenfeltSteven LangerPaul HincheyCatherine H. Choi - Albert Einstein College of MedicineThomas V. McDonaldFrancois V. BolducAmita Sehgal - Howard Hughes Medical InstituteSean M.J. McBride - Raymond and Ruth Perelman School of Medicine at the University of PennsylvaniaThomas A. Jongens - University of Pennsylvania
- Publication Details
- Molecular psychiatry, v 22(8), pp 1140-1148
- Publisher
- Springer Nature
- Number of pages
- 9
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine
- Web of Science ID
- WOS:000406046400009
- Scopus ID
- 2-s2.0-84964409630
- Other Identifier
- 991021904281304721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology
- Neurosciences
- Psychiatry