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Journal article
Insulin-like Growth Factor-1 (IGF-1) Improves both Neurological Motor and Cognitive Outcome Following Experimental Brain Injury
Experimental neurology, v 147(2), pp 418-427
Oct 1997
PMID: 9344566
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Abstract
We evaluated the efficacy of insulin-like growth factor-1 (IGF-1) in attenuating neurobehavioral deficits following lateral fluid percussion (FP) brain injury. Male Sprague–Dawley rats (345–425 g,n=88) were anesthetized and subjected to FP brain injury of moderate severity (2.4–2.9 atm). In Study 1, IGF-1 (1.0 mg/kg,n=9) or vehicle (n=14) was administered by subcutaneous injection at 15 min postinjury and similarly at 12-h intervals for 14 days. In animals evaluated daily for 14 days, IGF-1 treatment attenuated motor dysfunction over the 2-week period (P<0.02). In Study 2, IGF-1 (4 mg/kg/day,n=8 uninjured,n=13 injured) or vehicle (n=8 uninjured,n=13 injured) was administered for 2 weeks via a subcutaneous pump implanted 15 min postinjury. IGF-1 administration was associated with increased body weight and mild, transient hypoglycemia which was more pronounced in brain-injured animals. At 2 weeks postinjury (P<0.05), but not at 48 h or 1 week, brain-injured animals receiving IGF-1 showed improved neuromotor function compared with those receiving vehicle. IGF-1 administration also enhanced learning ability (P<0.03) and memory retention (P<0.01) in brain-injured animals at 2 weeks postinjury. Taken together, these data suggest that chronic, posttraumatic administration of the trophic factor IGF-1 may be efficacious in ameliorating neurobehavioral dysfunction associated with traumatic brain injury.
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Details
- Title
- Insulin-like Growth Factor-1 (IGF-1) Improves both Neurological Motor and Cognitive Outcome Following Experimental Brain Injury
- Creators
- Kathryn E. Saatman - University of PennsylvaniaPatricia C. Contreras - CephalonDouglas H. Smith - University of PennsylvaniaRamesh Raghupathi - University of PennsylvaniaKelli L. McDermott - University of PennsylvaniaSeamus C. Fernandez - University of PennsylvaniaKristin L. Sanderson - University of PennsylvaniaMadhu Voddi - University of PennsylvaniaTracy K. McIntosh - University of Pennsylvania
- Publication Details
- Experimental neurology, v 147(2), pp 418-427
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:A1997YC68000022
- Scopus ID
- 2-s2.0-0031257758
- Other Identifier
- 991019222889804721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- Web of Science research areas
- Neurosciences