Journal article
Intact fetal cells in maternal plasma: are they really there?
The Lancet (British edition), v 361(9352), pp 139-140
11 Jan 2003
PMID: 12531583
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Rare fetal cells can be recovered from maternal blood, which suggests that non-invasive prenatal diagnosis is possible. However, recovery and analysis of fetal cells from blood is complex, and sensitivity is low because of the rarity of these cells in the maternal circulation. An alternative strategy, which suggested that intact fetal cells can be found in maternal plasma by use of simple enrichment methods, has been reported. We aimed to replicate this technique. However, five independent laboratories were unable to identify any intact male cells from the plasma of 38 women known to be carrying male fetuses. Although apoptotic intact fetal cells could contribute to the detection of fetal DNA in maternal plasma, we believe that recovery of these cells is difficult and not clinically practical.
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Details
- Title
- Intact fetal cells in maternal plasma: are they really there?
- Creators
- Farideh Z Bischoff - Baylor College of MedicineSinuhe Hahn - University of BaselKirby L Johnson - Tufts UniversityJoe Leigh Simpson - Baylor College of MedicineDiana W Bianchi - Tufts UniversityDorothy E Lewis - Baylor College of MedicineWilliam D WeberKatherine KlingerSherman Elias - University of Illinois ChicagoLaird G Jackson - Hahnemann University HospitalMark I Evans - Hahnemann University HospitalWolfgang Holzgreve - University of BaselFelix de la Cruz
- Publication Details
- The Lancet (British edition), v 361(9352), pp 139-140
- Publisher
- Elsevier
- Grant note
- N01-HD-4-3203 / NICHD NIH HHS N01-HD-4-3204 / NICHD NIH HHS N01-HD-4-3201 / NICHD NIH HHS N01-HD-4-3202 / NICHD NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Medical College of Pennsylvania and Hahnemann University (1993-1996, 1998-2002)
- Web of Science ID
- WOS:000180428000015
- Scopus ID
- 2-s2.0-0037431770
- Other Identifier
- 991022200097804721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Medicine, General & Internal