Journal article
Integration of overlapping sequences emerges with consolidation through medial prefrontal cortex neural ensembles and hippocampal–cortical connectivity
eLife, v 13, e84359
15 Nov 2024
PMID: 39545928
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Systems consolidation theories propose two mechanisms that enable the behavioral integration of related memories: coordinated reactivation between hippocampus and cortex, and the emergence of cortical traces that reflect overlap across memories. However, there is limited empirical evidence that links these mechanisms to the emergence of behavioral integration over time. In two experiments, participants implicitly encoded sequences of objects with overlapping structure. Assessment of behavioral integration showed that response times during a recognition task reflected behavioral priming between objects that never occurred together in time but belonged to overlapping sequences. This priming was consolidation-dependent and only emerged for sequences learned 24 hr prior to the test. Critically, behavioral integration was related to changes in neural pattern similarity in the medial prefrontal cortex and increases in post-learning rest connectivity between the posterior hippocampus and lateral occipital cortex. These findings suggest that memories with a shared predictive structure become behaviorally integrated through a consolidation-related restructuring of the learned sequences, providing insight into the relationship between different consolidation mechanisms that support behavioral integration.
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Details
- Title
- Integration of overlapping sequences emerges with consolidation through medial prefrontal cortex neural ensembles and hippocampal–cortical connectivity
- Creators
- Alexa Tompary - Drexel UniversityLila Davachi - Columbia University
- Publication Details
- eLife, v 13, e84359
- Publisher
- eLIFE SCIENCES PUBL LTD; CAMBRIDGE
- Number of pages
- 38
- Grant note
- National Institute of Mental Health: MH074692 National Science FoundationDart Neuroscience
National Institute of Mental Health MH074692 Lila DavachiDart Neuroscience Lila DavachiNational Science Foundation GRFP Alexa Tompary
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychological and Brain Sciences (Psychology)
- Web of Science ID
- WOS:001394407600001
- Other Identifier
- 991021962114904721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Biology