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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Intensive Lifestyle Intervention Improves Physical Function Among Obese Adults With Knee Pain: Findings From the Look AHEAD Trial
Obesity (Silver Spring, Md.), v 19(1), pp 83-93
01 Jan 2011
PMID: 20559303
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Lifestyle interventions have resulted in weight loss or improved physical fitness among individuals with obesity, which may lead to improved physical function. This prospective investigation involved participants in the Action for Health in Diabetes (Look AHEAD) trial who reported knee pain at baseline (n = 2,203). The purposes of this investigation were to determine whether an Intensive Lifestyle Intervention (ILI) condition resulted in improvement in self-reported physical function from baseline to 12 months vs. a Diabetes Support and Education (DSE) condition, and whether changes in weight or fitness mediated the effect of the ILI. Outcome measures included the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain, stiffness, and physical function subscales, and WOMAC summary score. ILI participants exhibited greater adjusted mean weight loss (s.e.) vs. DSE participants (-9.02 kg (0.48) vs. -0.78 kg (0.49); P < 0.001)). ILI participants also demonstrated more favorable change in WOMAC summary scores vs. DSE participants (beta (s.e.) = -1.81 (0.63); P = 0.004). Multiple regression mediation analyses revealed that weight loss was a mediator of the effect of the ILI intervention on change in WOMAC pain, function, and summary scores (P < 0.001). In separate analyses, increased fitness also mediated the effect of the ILI intervention upon WOMAC summary score (P < 0.001). The ILI condition resulted in significant improvement in physical function among overweight and obese adults with diabetes and knee pain. The ILI condition also resulted in significant weight loss and improved fitness, which are possible mechanisms through which the ILI condition improved physical function.
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Details
- Title
- Intensive Lifestyle Intervention Improves Physical Function Among Obese Adults With Knee Pain: Findings From the Look AHEAD Trial
- Creators
- Capri G. Foy - Wake Forest UniversityCora E. Lewis - University of Alabama at BirminghamKristen G. Hairston - Wake Forest UniversityGary D. Miller - Wake Forest UniversityWei Lang - Wake Forest UniversityJohn M. Jakicic - University of PittsburghW. Jack Rejeski - University of Alabama at BirminghamPaul M. Ribisl - University of Alabama at BirminghamMichael P. Walkup - Wake Forest UniversityLynne E. Wagenknecht - Wake Forest UniversityLook AHEAD Res GrpEllen Stephanie Krauthamer Ewing - Drexel University
- Publication Details
- Obesity (Silver Spring, Md.), v 19(1), pp 83-93
- Publisher
- Wiley
- Number of pages
- 11
- Grant note
- Centers for Disease Control and Prevention; United States Department of Health & Human Services; Centers for Disease Control & Prevention - USA National Center on Minority Health and Health Disparities; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Minority Health & Health Disparities (NIMHD) National Heart, Lung, and Blood Institute; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) M01RR01066 / Massachusetts General Hospital Mallinckrodt General Clinical Research Center; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) M01RR01346 / Frederic C. Bartter General Clinical Research Center; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) M01RR02719 / Johns Hopkins Medical Institutions Bayview General Clinical Research Center; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) M01RR000056 / NATIONAL CENTER FOR RESEARCH RESOURCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) DK 046204 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA U01DK056992 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) National Institute of Nursing Research; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Nursing Research (NINR) M01RR00051 / University of Colorado Health Sciences Center General Clinical Research Center; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) University of Washington/VA Puget Sound Health Care System Medical Research Service, Department of Veterans Affairs; University of Washington; US Department of Veterans Affairs M01RR0021140 / University of Tennessee at Memphis General Clinical Research Center; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) National Institute of Diabetes and Digestive and Kidney Diseases; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) M01RR000056 44 / University of Pittsburgh General Clinical Research Center; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) P30DK48520 / Clinical Nutrition Research Unit DK57136; DK57149; DK56990; DK57177; DK57171; DK57151; DK57182; DK57131; DK57002; DK57078; DK57154; DK57178; DK57219; DK57008; DK57135; DK56992 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Office of Research on Women's Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Office of Research on Women's Health (ORWH)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Counseling and Family Therapy; Drexel University
- Web of Science ID
- WOS:000285633600015
- Scopus ID
- 2-s2.0-78650679300
- Other Identifier
- 991020099056004721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Endocrinology & Metabolism
- Nutrition & Dietetics