Journal article
Intentional weight loss and risk of lymphohematopoietic cancers
Cancer causes & control, v 21(2)
01 Feb 2010
PMID: 19851877
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
We hypothesized that intentional weight loss may be associated with development of lymphohematopoietic cancers, based on observations of immune suppression following weight loss in short-term studies.
At the baseline of the Women's Health Initiative Observational Study (1994-1998), participants reported information about intentional weight loss episodes in the past 20 years. We estimated hazard ratios (HRs) and 95% confidence intervals (CIs) among 81,219 women for associations between past intentional weight loss and risk of developing non-Hodgkin lymphoma (NHL), leukemia, and multiple myeloma during an average 9.9 years of follow-up.
The risk of NHL was associated with having lost a large maximum amount of weight (a parts per thousand yen50 pounds, HR = 1.68, 95% CI 1.13-2.50). NHL risk also varied by the frequency of intentional weight loss; women had increased risk if they lost 50 pounds or more a parts per thousand yen3 times (HR = 1.97, 95% CI 0.93-4.16; p trend by frequency = 0.09) or 20-49 pounds a parts per thousand yen3 times (HR = 1.55, 95% CI 1.00-2.40; p trend = 0.05), but there was no risk associated with smaller amounts of weight loss (10-19 pounds a parts per thousand yen3 times, HR = 0.78, 95% CI 0.46-1.33). These associations persisted with adjustment for body mass index at different ages. We observed non-significant associations of similar magnitude for multiple myeloma, but past intentional weight loss episodes were not associated with leukemia.
Further assessment of intentional weight loss as a possible risk factor for lymphomas may provide insight into the etiology of these cancers.
Metrics
Details
- Title
- Intentional weight loss and risk of lymphohematopoietic cancers
- Creators
- Anneclaire J. De Roos - Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South AfricaCornelia M. Ulrich - University of WashingtonRoberta M. Ray - Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South AfricaYasmin Mossavar-Rahmani - Albert Einstein Coll Med, Div Behav & Nutr Res, Dept Epidemiol & Populat Hlth, Bronx, NY 10467 USACarol A. Rosenberg - NorthShore Univ HealthSyst, Evanston, IL USABette J. Caan - Kaiser PermanenteCynthia A. Thomson - University of ArizonaAnne McTiernan - Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South AfricaAndrea Z. LaCroix - University of Washington
- Publication Details
- Cancer causes & control, v 21(2)
- Publisher
- Springer Nature
- Number of pages
- 14
- Grant note
- National Heart, Lung, and Blood Institute, US Department of Health and Human Services; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Environmental and Occupational Health
- Web of Science ID
- WOS:000273949200006
- Scopus ID
- 2-s2.0-77950690404
- Other Identifier
- 991020099801304721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Oncology
- Public, Environmental & Occupational Health