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Interaction between HIF-1α (ODD) and hARD1 does not induce acetylation and destabilization of HIF-1α
Journal article   Open access   Peer reviewed

Interaction between HIF-1α (ODD) and hARD1 does not induce acetylation and destabilization of HIF-1α

Thomas Arnesen, Xianguo Kong, Rune Evjenth, Darina Gromyko, Jan Erik Varhaug, Zhao Lin, Nianli Sang, Jaime Caro and Johan R. Lillehaug
FEBS letters, v 579(28), pp 6428-6432
21 Nov 2005
DOI: https://doi.org/10.1016/j.febslet.2005.10.036
PMID: 16288748
Featured in Collection :   UN Sustainable Development Goals @ Drexel
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https://doi.org/10.1016/j.febslet.2005.10.036View
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Abstract

Acetyltransferase Degradation Human ARD1 Hypoxia Hypoxia inducible factor-1α Protein acetylation
Hypoxia inducible factor-1α (HIF-1α) is a central component of the cellular responses to hypoxia. Hypoxic conditions result in stabilization of HIF-1α and formation of the transcriptionally active HIF-1 complex. It was suggested that mammalian ARD1 acetylates HIF-1α and thereby enhances HIF-1α ubiquitination and degradation. Furthermore, ARD1 was proposed to be downregulated in hypoxia thus facilitating the stabilization of HIF-1α. Here we demonstrate that the level of human ARD1 (hARD1) protein is not decreased in hypoxia. Moreover, hARD1 does not acetylate and destabilize HIF-1α. However, we find that hARD1 specifically binds HIF-1α, suggesting a putative, still unclear, connection between these proteins.

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Collaboration types
Domestic collaboration
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Web of Science research areas
Biochemistry & Molecular Biology
Biophysics
Cell Biology
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