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Interaction between phenanthrene and zinc in their toxicity to the sheepshead minnow (Cyprinodon variegatus)
Journal article   Peer reviewed

Interaction between phenanthrene and zinc in their toxicity to the sheepshead minnow (Cyprinodon variegatus)

C J Moreau, P L Klerks and C N Haas
Archives of environmental contamination and toxicology, v 37(2), pp 251-257
Aug 1999
DOI: https://doi.org/10.1007/s002449900512
PMID: 10398776

Abstract

Zinc - pharmacokinetics Animals Drug Interactions Water Pollutants, Chemical - toxicity Phenanthrenes - pharmacokinetics Water Pollutants, Chemical - pharmacokinetics Phenanthrenes - toxicity Zinc - toxicity Killifishes - metabolism Killifishes - physiology
Many contaminated sites contain a variety of toxicants. Risk assessment and the development of water quality criteria therefore require information on the interactive effects among toxicants in such mixtures. Interactions between metals are relatively well studied, but little is known about interactions between metals and hydrocarbons. This study investigated the interaction between phenanthrene and zinc in the sheepshead minnow Cyprinodon variegatus. Interaction studies were performed with 7-day-old minnows in 96-h bioassays with zinc and phenanthrene at a fixed ratio and with varying proportions of zinc and phenanthrene. Mixture toxicity was quantified with the toxic unit, additive index, and excess function methods. All three methods generally indicated an antagonistic interaction between phenanthrene and zinc, though the results also provide some evidence for a synergistic interaction at low toxicant levels or at specific phenanthrene-to-zinc ratios. Short-term uptake experiments were conducted to determine if the strong antagonistic interaction observed when zinc and phenanthrene were present at 50% of their LC50 values was due to effects of zinc and phenanthrene on each other's uptake. Significantly less 65Zn uptake occurred in the presence of phenanthrene than in its absence. In contrast, zinc did not appear to affect the uptake of 14C-phenanthrene.http://link. springer-ny.com/link/service/journals/00244/bibs/37n2p251.++ +html

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Domestic collaboration
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Environmental Sciences
Toxicology
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