Journal article
Interaction between rhythms in the human basal ganglia: application of bispectral analysis to local field potentials
Drexel University. School of Biomedical Engineering, Science, and Health Systems. Faculty Research and Publications.
04 Mar 2008
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The application of deep brain stimulation (DBS) for the treatment of Parkinson's disease offered a direct "insight" into the human electrical activity in subcortical structures. The analysis of the oscillatory activity [local field potentials (LFPs)] disclosed the importance of rhythms and of interactions between rhythms in the human basal ganglia information processing. The aim of this study wasto investigate the existence of possible nonlinear interactions between LFP rhythms characterizing the output structure of the basal ganglia, the globus pallidus internus, by means of bispectral analysis. The results of this study disclosed that the rhythms expressed in the globus pallidus internus of the untreated parkinsonian patient are not independent and, in particular, the low-beta (13–20Hz)band generates harmonics that are included in the high-beta (20–35 Hz) band. Conversely, in the dystonic globus pallidus, as well as in the parkinsonian globus pallidus afterdopaminergic medication (i.e., in the more "normal" condition), the rhythms are substantially independent and characterized by a strong activity in the low-frequency band that generates a second harmonic (4–14 Hz), mostly included in the same band. The interactions between rhythms in the human globus pallidus are therefore different in different pathologies and in different patient's states. The interpretation of these interactions is likely critical for fully understanding the role of LFP rhythms in the pathophysiology of human basal ganglia.
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Details
- Title
- Interaction between rhythms in the human basal ganglia: application of bispectral analysis to local field potentials
- Creators
- Sara Marceglia (Author) - Drexel University (1970-)Anna Maria Bianchi (Author) - Drexel University (1970-)Giuseppe Baselli (Author) - Drexel University (1970-)Guglielmo Foffani (Author) - Drexel University (1970-)Filippo Cogiamanian (Author) - Drexel University (1970-)Nicola Modugno (Author) - Drexel University (1970-)Simona Mrakic-Sposta (Author) - Drexel University (1970-)Alberto Priori (Author) - Drexel University (1970-)Sergio Cerutti (Author) - Drexel University (1970-)
- Publication Details
- Drexel University. School of Biomedical Engineering, Science, and Health Systems. Faculty Research and Publications.
- Publisher
- The Institute of Electrical and Electronics Engineers, Inc. (IEEE)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Drexel University (1970-); School of Biomedical Engineering, Science, and Health Systems
- Identifiers
- 991014632543504721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Engineering, Biomedical
- Rehabilitation