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Interactions of Subjective and Objective Measures of Fatigue Defined in the Context of Brain Control of Locomotion
Journal article   Open access   Peer reviewed

Interactions of Subjective and Objective Measures of Fatigue Defined in the Context of Brain Control of Locomotion

Roee Holtzer, Jennifer Yuan, Joe Verghese, Jeannette R Mahoney, Meltem Izzetoglu, Cuiling Wang and Jian-Min Yuan
The journals of gerontology. Series A, Biological sciences and medical sciences, v 72(3), pp 417-423
01 Mar 2017
DOI: https://doi.org/10.1093/gerona/glw167
PMID: 27567110
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.1093/gerona/glw167View
Published, Version of Record (VoR)Maybe Open Access (Publisher Bronze),  Open

Abstract

Aged Brain - physiology Diagnostic Self Evaluation Fatigue - diagnosis Fatigue - physiopathology Female Humans Locomotion Male Walking
Fatigue adversely impacts quality of life in old age. The relationship between subjective and objective measurements of fatigue, however, is poorly understood. We examined whether subjective fatigue moderated the expression of objective fatigue during locomotion. Associations between objective and subjective measures of fatigue were predicted to manifest only under dual-task conditions that maximized cognitive demands. Participants were 314 nondemented older adults (age = 76.8±6.7 years; % female = 56). Functional near-infrared spectroscopy was used to assess oxygenated hemoglobin (HbO2) levels during walking. A 4×14-foot Zeno electronic walkway was utilized to assess stride velocity (cm/s). Objective fatigue was operationalized as attenuation in HbO2 levels and decline in stride velocity (cm/s) during six continuous straight walks under single- (normal-walk) and dual-task (walk-while-talk) conditions. The Brief Fatigue Inventory assessed subjective fatigue. Worse subjective fatigue was associated with attenuated increase in HbO2 levels (estimate = 0.175; p < .05) but not with decline in stride velocity (estimate = 0.394; p > .05) from normal-walk to walk-while-talk conditions. Objective fatigue did not manifest and was not associated with subjective fatigue during the course of normal-walk. Worse subjective fatigue was associated with attenuated HbO2 levels in the fourth (estimate = -0.178; p < .05), fifth (estimate = -0.230; p < .01), and sixth (estimate = -0.231; p < .01) straight walks compared to the first during walk-while-talk. Dual-task walking paradigms provide a unique environment to simultaneously assess different facets of fatigue. The prefrontal cortex subserves both subjective and objective measurements of fatigue as defined in the context of attention-demanding locomotion.

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37 citations in Web of Science
37 citations in Scopus

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UN Sustainable Development Goals (SDGs)

This publication has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

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Collaboration types
Domestic collaboration
Web of Science research areas
Geriatrics & Gerontology
Gerontology
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