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Interactive Effects Between Exercise and Serotonergic Pharmacotherapy on Cortical Reorganization After Spinal Cord Injury
Journal article   Open access   Peer reviewed

Interactive Effects Between Exercise and Serotonergic Pharmacotherapy on Cortical Reorganization After Spinal Cord Injury

Guglielmo Foffani, Jed Shumsky, Eric B Knudsen, Patrick D Ganzer and Karen A Moxon
Neurorehabilitation and neural repair, v 30(5), pp 479-489
Jun 2016
DOI: https://doi.org/10.1177/1545968315600523
PMID: 26338432
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://europepmc.org/articles/pmc4777689View
Accepted (AM)Open Access (License Unspecified),  Open
url
https://doi.org/10.1177/1545968315600523View
Published, Version of Record (VoR) Open

Abstract

Action Potentials - drug effects Analysis of Variance Animals Cerebral Cortex - drug effects Cerebral Cortex - pathology Cerebral Cortex - physiology Disease Models, Animal Exercise Test Exercise Therapy - methods Exploratory Behavior - drug effects Exploratory Behavior - physiology Male Neurons - drug effects Neurons - physiology Quipazine - therapeutic use Rats Rats, Sprague-Dawley Serotonin Receptor Agonists - therapeutic use Spinal Cord Injuries - drug therapy Spinal Cord Injuries - pathology Spinal Cord Injuries - rehabilitation
In rat models of spinal cord injury, at least 3 different strategies can be used to promote long-term cortical reorganization: (1) active exercise above the level of the lesion; (2) passive exercise below the level of the lesion; and (3) serotonergic pharmacotherapy. Whether and how these potential therapeutic strategies-and their underlying mechanisms of action-interact remains unknown. Methods In spinally transected adult rats, we compared the effects of active exercise above the level of the lesion (treadmill), passive exercise below the level of the lesion (bike), serotonergic pharmacotherapy (quipazine), and combinations of the above therapies (bike+quipazine, treadmill+quipazine, bike+treadmill+quipazine) on long-term cortical reorganization (9 weeks after the spinal transection). Cortical reorganization was measured as the percentage of cells recorded in the deafferented hindlimb cortex that responded to tactile stimulation of the contralateral forelimb. Results Bike and quipazine are "competing" therapies for cortical reorganization, in the sense that quipazine limits the cortical reorganization induced by bike, whereas treadmill and quipazine are "collaborative" therapies, in the sense that the reorganization induced by quipazine combined with treadmill is greater than the reorganization induced by either quipazine or treadmill. These results uncover the interactive effects between active/passive exercise and serotonergic pharmacotherapy on cortical reorganization after spinal cord injury, emphasizing the importance of understanding the effects of therapeutic strategies in spinal cord injury (and in other forms of deafferentation) from an integrated system-level approach.

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13 citations in Web of Science
14 citations in Scopus

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UN Sustainable Development Goals (SDGs)

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#3 Good Health and Well-Being

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Collaboration types
Domestic collaboration
International collaboration
Web of Science research areas
Clinical Neurology
Rehabilitation
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