Journal article
Interferon Control of Human Coronavirus Infection and Viral Evasion: Mechanistic Insights and Implications for Antiviral Drug and Vaccine Development
Journal of molecular biology, v 434(6), 167438
30 Mar 2022
PMID: 34990653
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
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•HCoVs induce innate immune response via activation of multiple intracellular pattern recognition receptors.•HCoVs subvert the induction of innate immune response and signal transduction of IFNs via multiple mechanisms.•Innate immune response plays critical roles in HCoV pathogenesis.•Multiple IFN-induced proteins inhibit distinct steps of HCoV replication.
Recognition of viral infections by various pattern recognition receptors (PRRs) activates an inflammatory cytokine response that inhibits viral replication and orchestrates the activation of adaptive immune responses to control the viral infection. The broadly active innate immune response puts a strong selective pressure on viruses and drives the selection of variants with increased capabilities to subvert the induction and function of antiviral cytokines. This revolutionary process dynamically shapes the host ranges, cell tropism and pathogenesis of viruses. Recent studies on the innate immune responses to the infection of human coronaviruses (HCoV), particularly SARS-CoV-2, revealed that HCoV infections can be sensed by endosomal toll-like receptors and/or cytoplasmic RIG-I-like receptors in various cell types. However, the profiles of inflammatory cytokines and transcriptome response induced by a specific HCoV are usually cell type specific and determined by the virus-specific mechanisms of subverting the induction and function of interferons and inflammatory cytokines as well as the genetic trait of the host genes of innate immune pathways. We review herein the recent literatures on the innate immune responses and their roles in the pathogenesis of HCoV infections with emphasis on the pathobiological roles and therapeutic effects of type I interferons in HCoV infections and their antiviral mechanisms. The knowledge on the mechanism of innate immune control of HCoV infections and viral evasions should facilitate the development of therapeutics for induction of immune resolution of HCoV infections and vaccines for efficient control of COVID-19 pandemics and other HCoV infections.
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Details
- Title
- Interferon Control of Human Coronavirus Infection and Viral Evasion: Mechanistic Insights and Implications for Antiviral Drug and Vaccine Development
- Creators
- Xuesen Zhao - Capital Medical UniversityDanying Chen - Capital Medical UniversityXinglin Li - Capital Medical UniversityLauren Griffith - Baruch S. Blumberg InstituteJinhong Chang - Baruch S. Blumberg InstitutePing An - Frederick National Laboratory for Cancer ResearchJu-Tao Guo - Baruch S. Blumberg Institute
- Publication Details
- Journal of molecular biology, v 434(6), 167438
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000788241400014
- Scopus ID
- 2-s2.0-85123087584
- Other Identifier
- 991020547607504721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology