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Interferon-induced growth arrest is mediated by membrane structural changes
Journal article   Peer reviewed

Interferon-induced growth arrest is mediated by membrane structural changes

A Guha, R P Mason, D Primorac, G Konopaske, J Miller, P Sinha, T N Tulenko and A Hand
Journal of interferon & cytokine research, v 17(11), pp 701-706
01 Nov 1997
DOI: https://doi.org/10.1089/jir.1997.17.701
PMID: 9402108
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

Interferon-gamma (IFN-gamma) is an immunomodulator shown to augment the expression of major histocompatibility (MHC) class I/class II antigens on the cell surface. In previous studies, we have demonstrated that the enhanced expression of these antigens on the cell surface is in part due to IFN-gamma-mediated abrogation of antigen shedding. In this study, we demonstrate that IFN-gamma induces structural changes in the cell membrane by altering the cholesterol/phospholipid ratio. Furthermore, such changes not only mediate enhanced expression of antigen on the cell surface but may drive the cells to growth arrest and apoptosis. These results were obtained by employing x-ray diffraction, electron microscopy, and DNA analysis.

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3 citations in Web of Science
3 citations in Scopus

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Collaboration types
Domestic collaboration
Web of Science research areas
Biochemistry & Molecular Biology
Cell Biology
Immunology
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