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Journal article
Interferon induction of IFITM proteins promotes infection by human coronavirus OC43
Proceedings of the National Academy of Sciences - PNAS, v 111(18), pp 6756-6761
06 May 2014
PMID: 24753610
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
IFNs are a family of cytokines that are essential for the antiviral response in vertebrates. Not surprisingly, viruses have adapted to encode virulence factors to cope with the IFN response. Intriguingly, we show here that all three types of interferons, IFN-α, IFN-γ, and IFN-λ, efficiently promote infection by a human coronavirus, HCoV-OC43, one of the major etiological agents of common cold, through the induction of IFN-inducible transmembrane (IFITM) proteins. IFITMs typically exert their antiviral function by inhibiting the entry of a broad spectrum of viruses into their host cells, presumably by trapping and degrading invading virions within the endocytic compartments. In contrast, HCoV-OC43 uses IFN-induced human IFITM2 or IFITM3 as an entry factor to facilitate its infection of host cells. Reverse genetics analyses suggest that the structural motifs critical for the IFITM proteins' enhancement of HCoV-OC43 infection are distinct from those required for inhibiting infection by other viruses. We also present evidence showing that IFITM family members work as homo- and hetero-oligomers to modulate virus entry. The observed enhancement of HCoV-OC43 infection by IFNs may underlie the propensity of the virus to invade the lower respiratory tract under inflammatory conditions.
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Details
- Title
- Interferon induction of IFITM proteins promotes infection by human coronavirus OC43
- Creators
- Xuesen Zhao - Drexel Institute for Biotechnology and Virology Research, Department of Microbiology and Immunology, Drexel University College of Medicine, Doylestown, PA 18902Fang Guo - Drexel UniversityFei Liu - Drexel UniversityAndrea Cuconati - Hepatitis B FoundationJinhong Chang - Drexel UniversityTimothy M Block - Drexel UniversityJu-Tao Guo - Drexel University
- Publication Details
- Proceedings of the National Academy of Sciences - PNAS, v 111(18), pp 6756-6761
- Publisher
- PNAS
- Grant note
- AI104636 / NIAID NIH HHS P30 CA056036 / NCI NIH HHS R01 AI104636 / NIAID NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000335477300060
- Scopus ID
- 2-s2.0-84899804087
- Other Identifier
- 991019168689004721
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- Web of Science research areas
- Virology