Journal article
Interleukin 1 beta inhibition of TRH-stimulated prolactin secretion and phosphoinositides metabolism
Biochemical and biophysical research communications, v 165(1), pp 496-505
1989
PMID: 2556147
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The effect of interleukin 1 beta on prolactin secretion and on phosphoinositide turnover in anterior pituitary cells was evaluated. Interleukin 1 beta significantly inhibited TRH-stimulated prolactin secretion assessed by the reverse hemolytic plaque assay. In particular, the cytokine reduced the percentage of plaque forming cells, the plaque mean area, the large plaques percentage. TRH-stimulated inositol phosphate production was also significantly inhibited by interleukin 1 beta. This study shows that interleukin 1 beta reduces TRH-induced prolactin secretion through a direct action on pituitary cell, and attenuates the TRH-stimulated phosphoinositide breakdown. This latter effect may suggest that the reduced lactotropes sensitivity to TRH action may be partially due to interleukin 1 beta inhibition of phosphatidylinositol breakdown.
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Details
- Title
- Interleukin 1 beta inhibition of TRH-stimulated prolactin secretion and phosphoinositides metabolism
- Creators
- Gennaro Schettini - University of Naples Federico IIElisa Landolfi - University of Naples Federico IIMaurizio Grimaldi - University of Naples Federico IIOlimpia Meucci - University of Naples Federico IIAlfredo Postiglione - University of Naples Federico IITullio Florio - University of Naples Federico IICarmelo Ventra - University of Naples Federico II
- Publication Details
- Biochemical and biophysical research communications, v 165(1), pp 496-505
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:A1989CB54200073
- Scopus ID
- 2-s2.0-0024398778
- Other Identifier
- 991020111497904721
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Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biochemistry & Molecular Biology
- Biophysics