Journal article
Interleukin-15 Increases Effector Memory CD8+ T Cells and NK Cells in Simian Immunodeficiency Virus-Infected Macaques
Journal of virology, v 79(8), pp 4877-4885
Apr 2005
PMID: 15795273
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Interleukin-15 (IL-15) in vitro treatment of peripheral blood mononuclear cells (PBMC) from human immunodeficiency virus (HIV)-infected individuals specifically enhances the function and survival of HIV-specific CD8
+
T cells, while in vivo IL-15 treatment of mice preferentially expands memory CD8
+
T cells. In this study, we investigated the in vivo effect of IL-15 treatment in 9 SIVmac251-infected cynomolgus macaques (low dose of IL-15, 10 μg/kg of body weight,
n
= 3; high dose of IL-15, 100 μg/kg,
n
= 3; control [saline],
n
= 3; dose administered twice weekly for 4 weeks). IL-15 treatment induced a nearly threefold increase in peripheral blood CD8
+
CD3
−
NK cells. Furthermore, CD8
+
T-cell numbers increased more than twofold, mainly due to an increase in the CD45RA
−
CD62L
−
and CD45RA
+
CD62L
−
effector memory CD8
+
T cells. Expression of Ki-67 in the CD8
+
T cells indicated expansion of CD8
+
T cells and not redistribution. IL-15 did not affect CD4
+
T-cell, B-cell, and CD14
+
macrophage numbers. No statistically significant differences in changes from baseline in the viral load were observed when control-, low-dose-, and high-dose-treated animals were compared. No clinical adverse effects were observed in any of the animals studied. The selective expansion of effector memory CD8
+
T cells and NK cells by IL-15 further supports IL-15's possible therapeutic use in viral infections such as HIV infection.
Metrics
Details
- Title
- Interleukin-15 Increases Effector Memory CD8+ T Cells and NK Cells in Simian Immunodeficiency Virus-Infected Macaques
- Creators
- Yvonne M Mueller - Department of Microbiology and Immunology and Institute for Molecular Medicine and Infectious DiseaseConstantinos Petrovas - Department of Microbiology and Immunology and Institute for Molecular Medicine and Infectious DiseasePaul M Bojczuk - Department of Microbiology and Immunology and Institute for Molecular Medicine and Infectious DiseaseIoannis D Dimitriou - Department of Microbiology and Immunology and Institute for Molecular Medicine and Infectious DiseaseBrigitte Beer - Department of Microbiology and Immunology and Institute for Molecular Medicine and Infectious DiseasePeter Silvera - Department of Microbiology and Immunology and Institute for Molecular Medicine and Infectious DiseaseFrancois Villinger - Department of Microbiology and Immunology and Institute for Molecular Medicine and Infectious DiseaseJ. Scott Cairns - Department of Microbiology and Immunology and Institute for Molecular Medicine and Infectious DiseaseEdward J Gracely - Department of Microbiology and Immunology and Institute for Molecular Medicine and Infectious DiseaseMark G Lewis - Department of Microbiology and Immunology and Institute for Molecular Medicine and Infectious DiseasePeter D Katsikis - Department of Microbiology and Immunology and Institute for Molecular Medicine and Infectious Disease
- Publication Details
- Journal of virology, v 79(8), pp 4877-4885
- Publisher
- American Society for Microbiology
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- MD (Doctor of Medicine) Program
- Web of Science ID
- WOS:000228073700032
- Scopus ID
- 2-s2.0-20144386847
- Other Identifier
- 991014877936604721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- Web of Science research areas
- Virology